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Displaying 1941 – 1950 of 3789 Topics
Agency: HHS
Solicitation: PHS 201301 Open Period: 15-Aug-2012 to 03-Dec-2012
Topic Description: Summary Radiotherapy is employed in the treatment of over half of all cancer patients. Many of those patients suffer adverse effects during and/or after treatment. Additionally, tumors recur in approximately half the patients treated with curative intent. Enhancing specific tumor killing and… more
Agency: HHS
Solicitation: PHS 201301 Open Period: 15-Aug-2012 to 03-Dec-2012
Topic Description: Summary Medical imaging plays a key role in the clinical management of cancer patients. Cancer imaging agents are used in conjunction with medical imaging equipment, and, by highlighting the contrast between normal and malignant tissues, they allow the collection of information on cancer presence,… more
Agency: HHS
Solicitation: PHS 201301 Open Period: 15-Aug-2012 to 03-Dec-2012
Topic Description: Summary Radiation therapy is an important tool in the cancer treatment arsenal. Conventional radiotherapy with photons is currently used to treat 50% of all cancer patients. The success of radiation therapy and the risk of side effects depend heavily on the ability to concentrate radiation in the… more
Agency: HHS
Solicitation: PHS 201301 Open Period: 15-Aug-2012 to 03-Dec-2012
Topic Description: Translational science is very complex and can be characterized in a multitude of ways. Publications, grant applications, progress reports, funding, specific aims, study designs, hypotheses, outcomes, scientific evidence, experts, collaborations, organizations, and networks, as well as many other… more
Agency: HHS
Solicitation: PHS 201301 Open Period: 15-Aug-2012 to 03-Dec-2012
Topic Description: Creatine Transporter Deficiency (CTD) is a severe x-linked linked mental retardation disorder. It is caused by mutations in the creatine transporter gene (SLC68A). Mutations in this gene result in an inability to move creatine across the blood brain barrier. This inability to transport creatine… more
Agency: HHS
Solicitation: PHS 201301 Open Period: 15-Aug-2012 to 03-Dec-2012
Topic Description: This initiative seeks to develop an automated piece of instrumentation that can be used to clean previously used microtiter plates, making them suitable for reuse. Given the large quantities of microtiter plates required for high throughput screening any such device developed has the potential of a… more
Agency: HHS
Solicitation: PHS 201301 Open Period: 15-Aug-2012 to 03-Dec-2012
Topic Description: Adverse human health outcomes – a.k.a., “toxicity” – caused by pharmaceutical or environmental compounds are a major cause of drug development failure and public health concern. Methods to evaluate the potential of chemical compounds to induce toxicity are based largely on animal testing,… more
Agency: HHS
Solicitation: PHS 201301 Open Period: 15-Aug-2012 to 03-Dec-2012
Topic Description: Summary Myocardial fibrosis is a crucial marker of adverse cardiac remodeling. Research suggests a strong correlation between the extent of myocardial fibrosis and adverse myocardial remodeling that occurs after ischemic injury or during the progression of cardiomyopathies and heart failure. Diffuse… more
Agency: HHS
Solicitation: PHS 201301 Open Period: 15-Aug-2012 to 03-Dec-2012
Topic Description: Summary As a therapeutic option, an array of existing oral appliances are approved for the medical treatment of snoring and mild to moderate obstructive sleep apnea but lack specific capabilities necessary to fulfill regulatory requirements and conduct population-based effectiveness research.… more
Agency: HHS
Solicitation: PHS 201301 Open Period: 15-Aug-2012 to 03-Dec-2012
Topic Description: Summary Red blood cell (RBC) products for transfusion undergo metabolic and physical changes in both the cellular and plasma fractions during storage (RBCs can be stored up to 42 days currently) which may be associated with non-infectious risks and reduced tissue oxygenation capacity. The changes… more
Displaying 1941 – 1950 of 3789 Topics
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