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Displaying 1951 – 1960 of 3829 Topics
Agency: HHS
Solicitation: PHS 201301 Open Period: 15-Aug-2012 to 03-Dec-2012
Topic Description: Summary Clinical MRI systems use local surface receive devices (coils) to provide optimized signal to noise and enable fast imaging using parallel imaging techniques. These surface coils are designed for adult patients and function poorly for pediatric patients. Pediatric coils are targeted at a… more
Agency: HHS
Solicitation: PHS 201301 Open Period: 15-Aug-2012 to 03-Dec-2012
Topic Description: Summary Endomyocardial biopsies are performed approximately 10,000 times each year worldwide. The procedure suffers large anatomic sampling error because of no current appropriate image guidance. Endomyocardial biopsy is currently performed without targeting, whether under X-ray or ultrasound… more
Agency: HHS
Solicitation: PHS 201301 Open Period: 15-Aug-2012 to 03-Dec-2012
Topic Description: Summary MRI-guided catheter procedures can avoid radiation and may allow surgery to be avoided in a range of applications. A safe clinical guidewire is not commercially available. A complex “active” electronic MRI guidewire is being developed by DIR. However, a more simple and versatile… more
Agency: HHS
Solicitation: PHS 201301 Open Period: 15-Aug-2012 to 03-Dec-2012
Topic Description: Summary Implanting large appliances, such as mitral valve replacement, currently requires cardiac surgery and cardiopulmonary bypass. Minithoracotomy access remains high risk. NHLBI has shown early feasibility of direct transthoracic large-port access to the beating heart, and effective closure… more
Agency: HHS
Solicitation: PHS 201301 Open Period: 15-Aug-2012 to 03-Dec-2012
Topic Description: Summary Mechanical stents to relieve obstructive cardiovascular lesions could have great utility in pediatric cardiology, but are unsuitable for small children. Commercially available stents limit vessel growth and require future surgical removal. Absorbable stents might revolutionize the treatment… more
Agency: HHS
Solicitation: PHS 201301 Open Period: 15-Aug-2012 to 03-Dec-2012
Topic Description: Summary There is a need to develop a biocompatible fluorescent label that never photobleaches or blinks, and that is brighter than commonly used dyes. Fluorescent nanodiamonds (FNDs) are 10 to 100 nm sized biocompatible particles with indefinite photo-stability that make them superior imaging probes… more
Agency: HHS
Solicitation: PHS 201301 Open Period: 15-Aug-2012 to 03-Dec-2012
Topic Description: Background Many currently existing drugs for the treatment of TB, especially MDR TB are moderately potent, show restrictions with absorption or oral bioavailability, and have toxicity profiles that make patient management difficult. Aerosolized delivery offers the potential to bypass these barriers… more
Agency: HHS
Solicitation: PHS 201301 Open Period: 15-Aug-2012 to 03-Dec-2012
Topic Description: Background Effective treatment of HIV-infected individuals requires strict adherence to a multi-component regimen of antiretroviral agents that currently must be taken daily on a life-long basis. Non-compliance with recommended dosing regimens is a significant factor contributing to the incomplete… more
Agency: HHS
Solicitation: PHS 201301 Open Period: 15-Aug-2012 to 03-Dec-2012
Topic Description: Background There is an urgent need to develop alternative formulations of approved first and second line anti-TB drugs for pediatric use and also to simplify administration. There are few child-friendly formulations of pediatric first and second-line anti-TB medications available to practitioners in… more
Agency: HHS
Solicitation: PHS 201301 Open Period: 15-Aug-2012 to 03-Dec-2012
Topic Description: Background NIAID supports integrated multiplex medical diagnostics platforms capable of simultaneously identifying multiple pathogens in clinical specimens (swabs, sputum, blood, serum, cerebrospinal fluid, urine, stool, etc.). Platforms that provide diagnostic information on potential early,… more
Displaying 1951 – 1960 of 3829 Topics
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