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AN ATOM CLUSTER ION DESORPTION SOURCE

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
8114
Program Year/Program:
1988 / SBIR
Agency Tracking Number:
8114
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
ATOM SCIENCES, INC.
ATOM SCIENCES, INC. 114 RIDGEWAY CTR OAK RIDGE, TN 37830 8810
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1988
Title: AN ATOM CLUSTER ION DESORPTION SOURCE
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

THE NEED TO CHARACTERIZE COMPLEX ORGANIC COMPOUNDS FOR BIOTECHNOLOGY APPLICATIONS, SUCH AS PROTEIN SEQUENCING, HAS PLACED STRINGENT REQUIREMENTS ON THE DEVELOPMENT OF CHARACTERIZATION TOOLS. RECENT DEVELOPMENTS IN CLUSTER ION FORMATION AND ION BOMBARDMENT DESORPTION THEORY SUGGEST THATCLUSTER ION BOMBARDMENT OF COMPLEX MOLECULES MAY PROVIDE A MECHANISM TO CHARACTERIZE COMPLEX SPECIES AND SIGNIFICANTLY IMPROVE THE ABILITY TO SEQUENCE PROTEINS. THE SPECIFIC AIMSARE TO: 1) DEVELOP A SUPERSONIC NOZZLE TO PRODUCE HOMONUCLEAR ATOM CLUSTER DENSITIES UP TO 10(15) CM(-3); 2) MODIFY A TIME-OF-FLIGHT ION EXTRACTION SOURCE TO ACCOMMODATE THE LASER IONIZATION OF ATOM CLUSTERS; 3) EVALUATE THE CLUSTER ION DENSITIES AND SIZE DISTRIBUTIONS USING A MODIFIED TIME-OF-FLIGHT MASS SPECTROMETER; 4) DEMONSTRATE THE FEASIBILITY OF DESORBING HIGH MOLECULAR WEIGHT ORGANIC MOLECULES. THE SUCCESSFUL COMPLETION OF THESE AIMS IS EXPECTED TO RESULT IN A VERSATILE CLUSTER ION SOURCE TO DESORB NEUTRAL AND IONIZED HIGH MOLECULAR WEITHT ORGANIC COMPOUNDS, SUCH AS PEPTIDES AND PEPTIDE CHAINS. THE MOLECULES OR MOLECULAR IONS MAY BE FURTHER CHARACTERIZED USING EXISTING MASS SPECTROMETRIC AND LASER TECHNOLOGY. COMMERCIAL POTENTIAL INCLUDES THE DEVELOPMENT FOR SALE OF A SIMPLIFIED ATOM CLUSTER ION DESORPTION SOURCE (ACIDS) AND THE DEVELOPMENT OF AN APPLICATIONS MARKET FOR ANALYTICAL CHARACTERIZATION SERVICES FOR PROTEIN SEQUENCING.

Principal Investigator:


0

Business Contact:

Small Business Information at Submission:

Atom Sciences Inc
114 Ridgeway Ctr Oak Ridge, TN 37830

EIN/Tax ID:
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No