USA flag logo/image

An Official Website of the United States Government

ALUMINUM IN BRAIN DISEASES

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
8172
Program Year/Program:
1988 / SBIR
Agency Tracking Number:
8172
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
ATOM SCIENCES, INC.
ATOM SCIENCES, INC. 114 RIDGEWAY CTR OAK RIDGE, TN 37830 8810
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1988
Title: ALUMINUM IN BRAIN DISEASES
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

ALUMINUM HAS BEEN IMPLICATED IN NEUROLOGICAL AND AGING DISORDERS, INCLUDING ALZHEIMER'S DISEASE AND DIALYSIS DEMENTIA. PREVIOUS TRACE ANALYSIS STUDIES WERE SUBJECT TO INTERFERENCES AND CONTAMINATION, AND LACKED ELEMENTAL SPECIFICITY, SENSITIVITY, AND ISOTOPIC INFORMATION. RESONANCE IONIZATION SPECTROSCOPY (RIS), WHICH UTILIZES LASER ATOM COUNTING TECHNIQUES, OFFERS THE POTENTIAL TO OVERCOME THESE DISADVANTAGES AND TO PROBE DEEPLY THE MECHANISTIC ROLE OF ALUMINUM IN NEUROBIOLOGY. SPECIFIC AIMS ARE TO: 1) DEVELOP SIMPLIFIED CHEMICAL SEPARATION AND ATOMIZATION TECHNIQUES FOR ALUMINUM; 2) DEVELOP RESONANCE IONIZATION SCHEMES FOR ALUMINUM; 3) DEMONSTRATE THE FEASIBILITY OF ALUMINUM DETERMINATIONS IN BIOLOGICAL MATRICES; 4) ILLUSTRATE HOW THE TECHNOLOGY CAN BE APPLIED TO INVESTIGATE THE ROLE OF ALUMINUM IN NEUROLOGICAL DISORDERS. IN PHASE II THE KNOWLEDGE AND METHODOLOGY OF PHASE I WILL BE APPLIED TO SPECIFIC PROBLEMS OF ALUMINUM IN NEUROBIOLOGY. IT MAY BE POSSIBLE TO EVALUATE THE HYPOTHESISTHAT SPECIFIC NEUROLOGICAL DYSFUNCTIONS RESULT FROM ATTACHMENT OF ALUMINUM TO SPECIFIC CHEMICAL SITES IN SUBCELLULAR STRUCTURES. SUCH A CAPABILITY COULD LEAD TO DEVELOPING A MEANS OF EARLY DIAGNOSIS OF ONE OR MORE OF THESE DISORDERS. TECHNICAL BASES WILL BE ESTABLISHED FOR COMMERCIAL ALUMINUM ANALYSES CURRENTLY BEYOND THE STATE-OF-THE-ART, AND RIS INSTRUMENTATION WILL BE DISSEMINATED TO THE MEDICAL AND ANALYTICAL COMMUNITIES.

Principal Investigator:


0

Business Contact:

Small Business Information at Submission:

Atom Sciences Inc
114 Ridgeway Ctr Oak Ridge, TN 37830

EIN/Tax ID:
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No