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SNP DETECTION WITH UNLABELED, UNAMPLIFIED TARGET DNA

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
60203
Program Year/Program:
2002 / SBIR
Agency Tracking Number:
HG002404
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
ATOM SCIENCES, INC.
ATOM SCIENCES, INC. 114 RIDGEWAY CTR OAK RIDGE, TN 37830 8810
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2002
Title: SNP DETECTION WITH UNLABELED, UNAMPLIFIED TARGET DNA
Agency: HHS
Contract: 1R43HG002404-01
Award Amount: $99,427.00
 

Abstract:

DESCRIPTION (provided by applicant): The goal of the proposed project is to develop an analytical tool for large-scale detection of single-nucleotide polymorphisms (SNPs) in unlabeled, unamplified genomic or pooled nucleic acid samples. A dual hybridization utilizing a labeled, peptide nucleic acid (PNA, a nucleic acid analog) probe and an immobilized DNA probe will be performed. This innovative approach utilizes a long DNA probe to uniquely select the region of DNA near a specific gene and a short PNA probe that allows SNP identification. This simple method for SNP detection could be used in medical clinics for identifying disease causing mutations, such as human coagulation factor V Leiden, and in laboratories to study allele frequency and construct genetic maps. PROPOSED COMMERCIAL APPLICATIONS: This simple method for SNP detection would gain widespread acceptance in clinics for identifying genetic diseases and in laboratories to study allele frequency and construct genetic maps. Atom Sciences plans to market inexpensive kits that would use this technology.

Principal Investigator:

Wanda L. White
8654831113
WHITE@ATOM-SCI.COM

Business Contact:

Tom Whitaker
8654831113
WHITAKER@ATOM-SCI.COM
Small Business Information at Submission:

ATOM SCIENCES, INC.
ATOM SCIENCES, INC. 114 RIDGEWAY CTR OAK RIDGE, TN 37830

EIN/Tax ID: 621102077
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No