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Inexpensive Genetic Detection of Infectious Organisms

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
65895
Program Year/Program:
2003 / SBIR
Agency Tracking Number:
AI049596
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
ATOM SCIENCES, INC.
ATOM SCIENCES, INC. 114 RIDGEWAY CTR OAK RIDGE, TN 37830 8810
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2003
Title: Inexpensive Genetic Detection of Infectious Organisms
Agency: HHS
Contract: 2R44AI049596-02A1
Award Amount: $0.00
 

Abstract:

DESCRIPTION (provided by applicant): The aim of the research project is to develop a very inexpensive and rapid capacitance measurement technique that can be used as a diagnostic test to identify specific infectious organisms, their resistance to antimicrobial drugs, and their pathogenicity in a clinical setting. The goal is to make the cost so low that managed health organizations would encourage its use to identify pathogens and their resistance to antibiotics, thus greatly reducing the prescription of antibiotics in cases where they are ineffective, and consequently reducing one source of development of antimicrobial resistant strains of bacteria. The proposed diagnostic is based upon capacitance detection of DNA hybridization to probes on an array. In Phase I, we have demonstrated the technique works using both oligonucleotide and peptide nucleic acid (PNA) probes on coated gold insulators. We have also systematically explored the probe attachment and hybridization chemistry and their relationship to the stability of capacitance measurements on the array. In Phase II, we will continue to improve the chemistry and measurement hardware. We will also develop prototype arrays to detect some of the common pathogens encountered in a clinical setting.

Principal Investigator:

Tom J. Whitaker
8654831113
WHITAKER@ATOM-SCI.COM

Business Contact:

Tom Whitaker
8654831113
WHITAKER@ATOM-SCI.COM
Small Business Information at Submission:

ATOM SCIENCES, INC.
ATOM SCIENCES, INC. 114 RIDGEWAY CTR OAK RIDGE, TN 37830

EIN/Tax ID: 621102077
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No