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A BIODEGRADABLE, INJECTABLE DELIVERY SYSTEM FOR NSAIDS

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
13676
Program Year/Program:
1990 / SBIR
Agency Tracking Number:
13676
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
ATRIX LABORATORIES, INC.
2579 MIDPOINT DR Fort Collins, CO 80525
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1990
Title: A BIODEGRADABLE, INJECTABLE DELIVERY SYSTEM FOR NSAIDS
Agency: HHS
Contract: N/A
Award Amount: $49,000.00
 

Abstract:

IN THIS RESEARCH, NSAIDS WILL BE INDIVIDUALLY INCORPORATED INTO A DELIVERY SYSTEM. THE IN VITRO DELIVERY RATES WILL BEDETERMINED, AND THEN THE SYSTEM OPTIMIZED TO OBTAIN IN VITRO DELIVERY RATES OF 1 TO 12 WEEKS. THE VARIABLES THAT WILL BE EXAMINED TO OPTIMIZE RELEASE ARE POLYMER TYPE AND MOLECULAR WEIGHT, DRUG LOADING, AND BIOCOMPATIBLE PLASTICIZER CONTENT. FIVE NSAIDS WILL BE INDIVIDUALLY EVALUATED IN THE RELEASE SYSTEM: NAPROXEN, DICLOFENAC, PIROXICAM, SULINDAC, AND FLURBIPROFEN. THE MOST PROMISING FORMULATION WILL BE EVALUATED FOR TISSUE COMPATIBILITY IN PREPARATION FOR AN IN VITRO STUDY. THE DELIVERY SYSTEM TO BE STUDIED IS BIODEGRADABLE AND BIOCOMPATIBLE, AND IT HAS BEEN SHOWN TO CAUSE NO ADVERSE TISSUE REACTIONS IN ANIMAL TESTING. IT HAS BEEN STUDIED IN VITRO AND IN VIVO FOR THE CONTROLLED RELEASE OF SEVERAL DRUGS AND IS CURRENTLY BEING STUDIED IN HUMANS UNDER AN IND. MOST IMPORTANTLY, IT CAN BE INJECTED USING STANDARD SYRINGES AND NEEDLES.

Principal Investigator:

Arthur J Tipton
3034825868

Business Contact:

Small Business Information at Submission:

Atrix Laboratories Inc
1625 Sharp Point Dr Fort Collins, CO 80525

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No