The overall project objective is to develop a commercial software product to improve the resolution and allow for quantitative analysis of specimens imaged using differential interference contrast (DIC) microscopy, by reconstructing a map of the optical path length distribution. This will… More

The overall project objective is to develop a commercial software product to improve the resolution and allow for quantitative analysis of specimens imaged using differential interference contrast (DIC) microscopy, by reconstructing a map of the optical path length distribution. This will… More

This proposal seeks to improve the performance of density functional theory (DFT) as implemented in the commercial quantum chemistry software package Q-Chem. DFT strikes the right balance between accuracy and computational cost, and is used to model molecular processes in a wide variety of… More

DESCRIPTION (provided by applicant): The resolving power of the computer- and video-based light microscope is limited by two main factors. (1) It is limited by the optical resolving power of the microscope, which is -0.25 micro meter (2) It is limited by the pixel size.… More

DESCRIPTION (provided by applicant): Of the 5 percent of North Americans who develop diabetes, 4-15 percent develop macular edema about 8000 per annum register as legally blind. It is simple for the clinician to diagnosis localized (rather than diffuse) edema that has a marked (2 fold or… More

DESCRIPTION (provided by applicant): The objective of this project is to develop a commercial software product to improve the visualization and resolution of two-dimensional (2D) images obtained from optical microscopes. Diffraction and other optical distortions present in every 2D microscope… More

DESCRIPTION (provided by applicant): The objective of this project is to develop a commercial software product to improve the visualization and resolution of two-dimensional (2D) images obtained from optical microscopes. Diffraction and other optical distortions present in every 2D microscope… More

DESCRIPTION (provided by applicant): Fluorescence resonance energy transfer (FRET) imaging is a microscope technique that uses a dye pair. It detects bonding of proteins, and in turn, is used to deduce many activities such as chromosome dynamics through the cell cycle. When one dye (the donor),… More

DESCRIPTION (provided by applicant): The time lapse 3D microscope imaging of living cells is widely used in many biomedical research areas. This technique potentially generates hundreds of image volumes in a single experiment, which are critical to the visualization and quantification of… More

DESCRIPTION (provided by applicant): The confocal fluorescent microscope directly eliminates the light emitted from out-of-focus internal structures. This has enabled the observation of fluorophore-labeled processes or 3D structures deep within thick specimens. Unfortunately, high performance… More

X-ray computed tomography (CT) is used to evaluate the integrity of solid rocket motors (SRM's) used in the missile defense fleet. There is a need for better visualization of bondlines of materials, and detection of flaws, especially in the SRM's dome region. This problem is due to partial volume… More

DESCRIPTION (provided by applicant): The main objective of this SBIR Phase I research is to develop and test a software prototype. The prototype will lead to a software product. It will be a clinical tool that helps clinicians to assess the condition of pa tients who are at risk of or who have… More

DESCRIPTION (provided by applicant): Indocyanine Green (ICG) and Sodium Fluorescein (SF) are fluorescent dyes used clinically in eye fundus imaging, primarily for detecting vascular abnormalities in the retina and choroid, which is the layer behind the ret ina. It is used with the Heidelberg Retinal… More

The Phase I objective is a conceptual design of a hyperspectral/multimodal fundus camera for assessing laser damage. The premise to be ultimately proven in this project is that damage to the fundus, from laser irradiation, may be characterized and detected by reflectance spectra, and by measuring… More

X-ray computed tomography (CT) is used to evaluate the integrity and aging of solid rocket motors (SRM) used in missile defense. There is a need for better vizualization of bondlines of materials, and the detection of their flaws, in the dome region. This problem is due to partial volume effects… More

The objective of Phase I is the preliminary design, prototype and testing of a 3D spectral imaging system for the characterization and evaluation of viability of engineered tissue for treating war injuries. The purpose is in ensuring tissue viability, maturity, vascularity to know if a construct is… More

ABSTRACT: High Energy X-ray computed tomography (CT) is used to inspect and evaluate the integrity of solid rocket motors (SRM"s). The driving purpose of this proposal is to improve the detection of defects in special cases where the defects are obscured due to limitations of the CT images. … More

DESCRIPTION (provided by applicant): This research will have a significant and potentially broad impact on reducing blindness and vision loss of Americans. Many predominant eye conditions, associated with blindness and vision loss, disturb and compromise the photoreceptors. This research will enable… More