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Novel Therapeutic Agents for Diabetic Ulcers

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R41DK078438-01A1
Agency Tracking Number: DK078438
Amount: $182,189.00
Phase: Phase I
Program: STTR
Solicitation Topic Code: N/A
Solicitation Number: PHS2007-2
Timeline
Solicitation Year: 2008
Award Year: 2008
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
AUXAGEN, INC. 7 PRICEWOODS
SAINT LOUIS, MO 63132
United States
DUNS: 153650655
HUBZone Owned: No
Woman Owned: Yes
Socially and Economically Disadvantaged: No
Principal Investigator
 JUNG HUANG
 (314) 977-9250
 HUANGJS@SLU.EDU
Business Contact
Phone: (314) 993-2508
Research Institution
N/A
Abstract

DESCRIPTION (provided by applicant): Diabetes mellitus afflicts 20.8 million people, or 7% of the population, in the United States. Fifteen percent, or 2.4 million people, will develop diabetic foot ulcers in their life time. Diabetic foot ulceration and i
nfections are a major cause of hospitalization of diabetic patients. The direct and indirect costs of ulcer management and treatment exceed 10 billion dollars per year. In spite of this, approximately 1000 amputations are still performed on people with dia
betes each week in the USA due to the lack of effective therapy for diabetic foot ulcers. Attempts to treat diabetic foot ulcers with growth factors have resulted in little success. Increasing evidence indicates that TGF-a is involved in the early and late
phases of peripheral neuropathy and microvascular disease, both of which contribute to the development of diabetic foot ulcers. In diabetic patients, the plasma level of TGF-a is increased; TGF-a expression is also increased in diabetic wounds. TGF-a is a
potent chemoattractant for inflammatory cells and inhibitor of endothelial and epithelial cell growth. It has been implicated in prolonged inflammation, defective angiogenesis and retarded wound re-epithelialization, as seen in diabetic foot ulcers. TGF-a
appears to be an ideal therapeutic target for treating diabetic foot ulcers. However, no effective TGF-a antagonists have been developed. Recently, we developed TGF-a peptide antagonists (termed TGF-a peptantagonists) which are the only known TGF-a recept
or antagonists and have been shown to accelerate normal wound healing in several animal burn/excision wound models. The efficacy of TGF-a peptantagonists in accelerating wound healing is limited by its poor solubility in aqueous solutions at neutral pH. Th
e proposed research aims at developing novel TGF-a antagonists with excellent solubility, potent activity and high wound-penetration activity, based on the current chemical forms of TGF-a peptantagonists. The new forms of TGF-a peptantagonists developed in
these studies should be excellent candidate drugs for treating diabetic foot ulcers. PUBLIC HEALTH RELEVANCE the goal of this project is to develop therapeutic agents for diabetic foot ulcers which currently lack effective treatments. The novel antagonist
s developed in this project should be ideal drug candidates for treating diabetic foot ulcers in humans.

* Information listed above is at the time of submission. *

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