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Short-Wavelength Countermeasure for Circadian Desynchrony

Award Information

Agency:
Department of Defense
Branch:
Air Force
Award ID:
83336
Program Year/Program:
2007 / STTR
Agency Tracking Number:
F074-015-0066
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
AVAcore Technologies, Inc.
333 Parkland Plaza Drive Suite 700 Ann Arbor, MI 48103
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2007
Title: Short-Wavelength Countermeasure for Circadian Desynchrony
Agency / Branch: DOD / USAF
Contract: FA9550-07-C-0111
Award Amount: $99,969.00
 

Abstract:

Exposure to light at critical phases of the circadian cycle is the main stimulus that phase shifts and entrains circadian rhythms. Whereas previous work has concluded that exposure of humans to bright light for an hour or more at the right phase of the circadian cycle produces significant phase shifts of circadian rhythms, and can speed recovery from jet-lag thus facilitating restorative sleep. Our work on mice has produced the unexpected result that exposure of the animals to intermittent millisecond flashes of light distributed over an hour for a total of only 120 msec. of light can produce maximum phase shifts. We have also shown that the effects of light on the circadian system of mice is mediated through a unique photopigment - melanopsin, and the properties of this system explain the effectiveness of brief flashes of light as entraining signals. We propose a proof of concept study to demonstrate whether or not millisecond flashes of light can phase shift the human circadian system. On the basis of these results, we will develop a phase shifting device for military and commercial applications.

Principal Investigator:

H. C. Heller
Professor
6507231509
hcheller@stanford.edu

Business Contact:

Charles Hixson
President
7343323777
carlosdelnorte@sbcglobal.net
Small Business Information at Submission:

AVACORE TECHNOLOGIES, INC.
333 Parkland Plaza Drive Suite 700 Ann Arbor, CA 48103

EIN/Tax ID: 770546793
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Research Institution Information:
STANFORD UNIV.
Office of Sponsored Research
651 Serra Mall
Stanford, CA 94305 6203
Contact: Blanca Rebuelta
Contact Phone: (650) 725-0515
RI Type: Nonprofit college or university