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A Microneedle Array System for Transcutaneous Nerve Mapping

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
94065
Program Year/Program:
2009 / SBIR
Agency Tracking Number:
NS065545
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
AXION BIOSYSTEMS, LLC
311 Ferst Drive ATLANTA, GA 30332-
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2009
Title: A Microneedle Array System for Transcutaneous Nerve Mapping
Agency: HHS
Contract: 1R43NS065545-01A1
Award Amount: $556,989.00
 

Abstract:

DESCRIPTION (provided by applicant): The proposed study utilizes novel electronics and microfabrication techniques to create a non-invasive, automated platform for targeted monitoring and manipulation of human neural tissue. This research will enable rapid advancements in both basic research and clinical medical devices, with applications to neuropathological diagnostics, advanced therapeutics, and neural prosthetics. Phase I involves three significant developments for non-invasive neurotechnology. Aim 1 wi ll develop high-resolution and low-noise skin surface electrode arrays. Each electrode within the array will contain low-cost micropat- terned needles, which dramatically decrease electrode impedance by painlessly piercing the topmost layer of skin, allowi ng for high spatial resolution without any sacrifice in signal-to-noise ratios. Aim 2 will develop scalable simultaneous stimulation and re- cording electronics to recover signals traditionally obscured by stimulation artifacts. The recovered data, combine d with the ability to simultaneously interact with dozens of skin- surface electrodes, will provide new measures of transcutaneous nerve and muscle activ- ity. Finally, Aim 3 will combine the technological developments of Aims 1 and 2 to dem- onstrate the segmentation and characterization of nerves through the skin. In addition to reducing the complexity, pain, and operator training required to perform traditional nerve conduction studies (NCS), this platform will enable a wide range of basic research studi es as well as the creation of novel neuromodulation devices. Phase 2 will focus on increasing the number of channels serviced by the array and electronics, reducing the form factor and processing requirements for the electronics, and providing signal- proc essing hardware and algorithms for real-time information extraction and neural control. PUBLIC HEALTH RELEVANCE: This research project leverages novel electronic and fabrication technologies to produce a non-invasive automated toolset for the study of nerv e, muscle, and brain tissue. Ulti- mately, this development will facilitate medical and scientific discoveries that will enable the diagnosis and therapeutic treatment of neuromuscular diseases.

Principal Investigator:

James Ross

Business Contact:

Ross
Small Business Information at Submission:

AXION BIOSYSTEMS, LLC
AXION BIOSYSTEMS, LLC 1186 LARCH LN DECATUR, GA 30033

EIN/Tax ID: 130047234
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No