DESCRIPTION (provided by applicant): Injury is the leading cause of mortality among Americans under 45 years of age, and traumatic brain injury (TBI) is responsible for the majority of these deaths. The absence of clinically useful diagnostics has severely impeded effective management and treatment… More

Stroke is the second leading cause of death worldwide and the primary cause of serious, long-term disability and nursing home admissions. The absence of clinically useful diagnostics has severely impeded effective management and treatment of acute ischemic stroke. Currently available diagnostics are… More

Traumatic brain injury (TBI) is a leading cause of combat casualty. Previous estimates for 20th century conflicts were that 15 - 25% of all injuries were sustained to the head. However, with the increased incidence of blast injuries that military personnel are suffering in the current conflicts in… More

DESCRIPTION (provided by applicant): Liver injury induced by hepatic ischemia followed by reperfusion is a major pathogenic cause of liver failure during multiple trauma, thermal injury, hemorrhagic and septic shock, and liver transplantation, which contributes significantly to multiple organ… More

DESCRIPTION (provided by applicant): Each year in the United States at least 1.4 million people seek medical attention for a traumatic brain injury (TBI). Between 75% and 90% of these are mild or moderate injuries. These can inflict profound and persistent impairment of physical, cognitive, and… More

DESCRIPTION (provided by applicant): Liver damage and failure due to various forms of hepatic injury is a significant source of overall morbidity and mortality in the US and worldwide. Persistent hepatic injury occurs during viral hepatitis, fatty liver di sease (steatohepatitis), drug or alcohol… More

DESCRIPTION (provided by applicant): Multiorgan injury and failure due to septic complications result in significant morbidity and mortality, especially in pediatric and elderly patients with severe bacterial infections. Pathogenesis of endotoxic shock/sepsis has not been understood in great detail,… More