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Novel Biomarkers for Traumatic Brain Injury

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
71810
Program Year/Program:
2004 / SBIR
Agency Tracking Number:
NS048685
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
BANYAN BIOMARKERS, INC.
12085 RESEARCH DR ALACHUA, FL 32615-
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2004
Title: Novel Biomarkers for Traumatic Brain Injury
Agency: HHS
Contract: 1R43NS048685-01
Award Amount: $100,000.00
 

Abstract:

DESCRIPTION (provided by applicant): Injury is the leading cause of mortality among Americans under 45 years of age, and traumatic brain injury (TBI) is responsible for the majority of these deaths. The absence of clinically useful diagnostics has severely impeded effective management and treatment of TBI. Currently available diagnostics are either expensive and/or unreliable and, there are no simple, rapid, non-invasive tests to diagnose and assess the magnitude of TBI, as well as to predict outcome. Immunoassay technology, such as the enzyme-linked immunosorbent assay (ELISA) method can be employed to develop this much-needed TBI diagnostic test. Such a test would also help predict the efficacy of potential therapies to treat injury as well as provide information on precise biochemical and molecular mechanisms contributing to injury, recovery of function and/or therapeutic effectiveness. We have developed a specific and sensitive biomarker for TBI that preliminary experiments show to be correlated with severity of injury and sensitive to therapeutic intervention. Moreover, this biomarker provides direct assessments of pathobiological mechanisms involved in destruction of the cytoskeletal protein, alpha II-spectrin (spectrin breakdown product 150; SBDP150). THE OVERALL OBJECTIVE OF THIS PROPOSAL IS TO DEVELOP A NOVEL DIAGNOSTIC PROTOTYPE ELISA KIT FOR THE QUANTITATIVE DETERMINATION OF THE SBDP150 BIOMARKER IN CEREBROSPINAL FLUID (CSF). Specific Aim 1: Configuration of sandwich ELISA for the quantitative and specific detection of a calpain mediated SBDP150. Deliverable from Specific Aim 1: Configuration of a diagnostic ELISA kit for the quantitative detection of SBDP150. (Months 0-4) Specific Aim 2: Preliminary validation of the utility of the SBDP150 sandwich ELISA in a rat model of TBI. Deliverable from Specific Aim 2: Prototype diagnostic ELISA capable of measuring SBDP150 levels in CSF and sensitive to different injury magnitudes. (Months 5-6)

Principal Investigator:

Dennis M. Tomisaka
3864626699
DTOMISAKA@BANYANBIO.COM

Business Contact:


3864626699
Small Business Information at Submission:

BANYAN BIOMARKERS, INC.
BANYAN BIOMARKERS, INC. 12085 RESEARCH DR, STE 122 ALACHUA, FL 32615

EIN/Tax ID: 020573903
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No