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Company Information:

Company Name: BARLOW SCIENTIFIC, INC.
City: OLYMPIA
State: WA
Zip+4: 98502-
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Website URL: N/A
Phone: N/A

Award Totals:

Program/Phase Award Amount ($) Number of Awards
SBIR Phase I $1,597,499.00 23
SBIR Phase II $7,672,993.00 14
STTR Phase I $100,000.00 1

Award List:

NONINVASIVE MONITORING OF KIDNEYS AWAITING TRANSPLANT

Award Year / Program / Phase: 1987 / SBIR / Phase I
Agency: HHS
Principal Investigator: Clyde h barlow phd
Award Amount: $50,000.00
Abstract:
The long-term gosl of this research is to construct and evaluate a noninvasive device that will assess the functional integrity of hypothermic perfused kidneys prior to transplant. the device is based on measurements of changes in mitochondrial electron-transport protein-oxidation states in the… More

NADH FLUORESCENCE IMAGING IN THE HEART

Award Year / Program / Phase: 1987 / SBIR / Phase I
Agency: HHS
Principal Investigator: Clyde H Barlow Phd
Award Amount: $50,000.00

DIGITAL IMAGING FOR SKIN GRAFT VIABILITY

Award Year / Program / Phase: 1988 / SBIR / Phase I
Agency: HHS
Principal Investigator:
Award Amount: $50,000.00

NADH FLUORESCENCE IMAGING IN THE HEART

Award Year / Program / Phase: 1989 / SBIR / Phase II
Agency: HHS
Principal Investigator: Clyde H Barlow Phd
Award Amount: $386,461.00
Abstract:
The long-term goal of this research is to develop quantitative imaging methods for tissue bioenergetic studies. toward this end, it is proposed to construct and evaluate an instrument that will image the response of mitochondrial metabolites to ischemia and hypoxia in rabbit hearts in situ.… More

EPICARDIAL OXYGEN MONITOR

Award Year / Program / Phase: 1989 / SBIR / Phase I
Agency: HHS
Principal Investigator:
Award Amount: $50,000.00

DIGITAL IMAGING FOR SKIN GRAFT VIABILITY

Award Year / Program / Phase: 1990 / SBIR / Phase II
Agency: HHS
Principal Investigator:
Award Amount: $373,485.00
Abstract:
The long term goal of this research is to develop an imaging system to evaluate viability of vascularized skin grafts. towards this end it is proposed to construct and evaluate a digitized imager that will visually display two parameters that correlate with skin graft viability. the first technique… More

TISSUE TEMPERATURE BY NEAR-INFRARED SPECTROSCOPY

Award Year / Program / Phase: 1990 / SBIR / Phase I
Agency: HHS
Principal Investigator: Jeffrey J Kelly
Award Amount: $49,391.00
Abstract:
The long-term goal of this research is to develop optical instruments and methods for measuring and imaging tissue temperature. in phase i, techniques will be developed that compute temperature readings from near-infrared (nir) absorption bands of water. the effect of interference on such… More

EPICARDIAL OXYGEN MONITOR

Award Year / Program / Phase: 1991 / SBIR / Phase II
Agency: HHS
Principal Investigator:
Award Amount: $334,093.00
Abstract:
The long-term goal of this research is to develop quantitative optical imaging methods for bioenergetic studies of tissue. methods will be developed for the optical determination of tissue or circulatory oxygen concentration based on palladium porphyrin phosphorescence quenching by collisional… More

FIBER OPTIC REFLECTANCE/PHOSPHORESCENCE DECAY SPECTROMETRY

Award Year / Program / Phase: 1992 / SBIR / Phase I
Agency: HHS
Principal Investigator: Clyde H Barlow
Award Amount: $50,000.00

FIBER OPTIC REFLECTANCE/PHOSPHORESCENCE DECAY SPECTROMETRY

Award Year / Program / Phase: 1993 / SBIR / Phase II
Agency: HHS
Principal Investigator: Clyde H Barlow
Award Amount: $466,669.00
Abstract:
This research project involves the development of optical methods to quantify the total available oxygen content of opicardial tissue. epicardial oxygen is found in three major pools-as oxygen dissolved in aqueous media, as oxygen bound to hemoblobin and as oxygen bound to myoglobin. in this… More

Regional Flow Imaging by Fluorescent Microspheres

Award Year / Program / Phase: 1993 / SBIR / Phase I
Agency: HHS
Principal Investigator: Clyde H. Barlow
Award Amount: $49,999.00

Metabolic Imaging of Livers Awaiting Transplant

Award Year / Program / Phase: 1993 / SBIR / Phase I
Agency: HHS
Principal Investigator: Jeffrey J. Kelly
Award Amount: $50,000.00

Diagnostic Imaging of Skin

Award Year / Program / Phase: 1994 / SBIR / Phase I
Agency: HHS
Principal Investigator: Jeffrey Kelly
Award Amount: $75,000.00
Abstract:
This research will develop an optical instrument to aid in the noninvasive evaluation of skinaffected by injury, surgical procedures and/or disease. The instrument will use characteristics of lightabsorption by hemoglobin species to delineate skin regions compromised by ischemia, hypoxia ornecrosis.… More

Regional Flow Imaging by Fluorescent Microspheres

Award Year / Program / Phase: 1995 / SBIR / Phase II
Agency: HHS
Principal Investigator: Clyde H. Barlow
Award Amount: $596,945.00
Abstract:
We will develop a new approach to the evaluation of microregional circulation. This research is based on the working hypothesis that fluorescent microspheres can be spatially located by fluorescence imaging of organ serial sections. The project will develop instrumentation and procedures to evaluate… More

Metabolic Imaging of Livers Awaiting Transplant

Award Year / Program / Phase: 1995 / SBIR / Phase II
Agency: HHS
Principal Investigator: Jeffrey J. Kelly
Award Amount: $572,842.00
Abstract:
The long term goal is to develop noninvasive optical instruments and methods for assessing the functional integrity of cold-stored livers prior to transplant. In hypothermically-stored livers, areas of dysfunctional oxidative metabolism can be detected noninvasively using spectrophotometric methods.… More

Fluorescent Microsphere Counting for Flow Measurements

Award Year / Program / Phase: 1995 / SBIR / Phase I
Agency: HHS
Principal Investigator: Clyde Barlow
Award Amount: $74,470.00

Morphometric Analysis of Pressure Ulcers

Award Year / Program / Phase: 1995 / SBIR / Phase I
Agency: HHS
Principal Investigator: Jeffrey Kelly
Award Amount: $99,771.00

Morphometric Analysis of Pressure Ulcers

Award Year / Program / Phase: 1997 / SBIR / Phase II
Agency: HHS
Principal Investigator: Jeffrey Kelly
Award Amount: $617,218.00
Abstract:
This research will develop an instrument to aid in the rapid, non-invasive measurement of ulcer sizhealing. The device will quantitative wound volume using a structured laser light, with optical imagcurve-fitting methodologies. This research is based on the hypothesis that when structured light… More

Fluorescent Microsphere Counting for Flow Measurements

Award Year / Program / Phase: 1997 / SBIR / Phase II
Agency: HHS
Principal Investigator: Clyde Barlow
Award Amount: $555,699.00
Abstract:
We will develop low cost and accurate methods for regional flow measurements in tissues. This reseaon the working hypothesis that fluorescent microspheres in tissue digests can be accurately and rapifluorescence flow system. The project will develop instrumentation and evaluate procedures to… More

FLUORESCENCE IMAGING OF REGIONAL FLOW IN HEART

Award Year / Program / Phase: 1997 / SBIR / Phase I
Agency: HHS
Principal Investigator: Kelly, jeffrey j
Award Amount: $99,999.00

N/A

Award Year / Program / Phase: 1999 / SBIR / Phase II
Agency: HHS
Principal Investigator: Kelly jeffrey j
Award Amount: $744,910.00

IMAGE ANALYSIS OF VASCULAR CASTS

Award Year / Program / Phase: 1999 / SBIR / Phase I
Agency: HHS
Principal Investigator: Clyde H. Barlow
Award Amount: $100,000.00

SIMPLIFIED MEASUREMENT OF REGIONAL FLOW

Award Year / Program / Phase: 1999 / SBIR / Phase I
Agency: HHS
Principal Investigator: Jeffrey J. Kelly
Award Amount: $100,000.00

N/A

Award Year / Program / Phase: 2000 / SBIR / Phase I
Agency: HHS
Principal Investigator: Clyde H. Barlow
Award Amount: $0.00

N/A

Award Year / Program / Phase: 2000 / SBIR / Phase II
Agency: HHS
Principal Investigator: Clyde H. Barlow
Award Amount: $427,717.00

SIMPLIFIED MEASUREMENT OF REGIONAL FLOW

Award Year / Program / Phase: 2001 / SBIR / Phase I
Agency: HHS
Principal Investigator: Jeffrey J. Kelly
Award Amount: $0.00

SIMPLIFIED MEASUREMENT OF REGIONAL FLOW

Award Year / Program / Phase: 2001 / SBIR / Phase II
Agency: HHS
Principal Investigator: Jeffrey J. Kelly
Award Amount: $382,443.00

REGIONAL FLOW MEASUREMENT IN TUMORS

Award Year / Program / Phase: 2001 / SBIR / Phase I
Agency: HHS
Principal Investigator: Clyde H. Barlow
Award Amount: $98,869.00
Abstract:
DESCRIPTION (Verbatim From Applicant's Abstract): The goal of this project is to develop a fully automated method and instrument for high-resolution three-dimensional mapping of regional blood flow distribution in tumors. This research is based upon the working hypothesis… More

ANTIBODY IMAGING FOR REGIONAL FLOW MEASUREMENTS

Award Year / Program / Phase: 2002 / SBIR / Phase I
Agency: HHS
Principal Investigator: Jeffrey J. Kelly
Award Amount: $100,000.00
Abstract:
This research involves developing procedures to determine regional flow in tissues and organs at high resolution. Current methods for regional flow determinations are limited by microsphere size and counting statistics. This study tests the hypothesis that fluorescently-labeled antibodies, serving… More

REGIONAL FLOW MEASUREMENTS IN TUMORS

Award Year / Program / Phase: 2003 / SBIR / Phase I
Agency: HHS
Principal Investigator: Clyde H. Barlow
Award Amount: $0.00
Abstract:
DESCRIPTION (provided by applicant): In order for a tumor to grow, it must obtain nutrients and oxygen from its host and continuously evolve new vasculature to deliver supplies to its multiplying cells. Exciting current research studies of interventions that reduce or reverse malignant growth of… More

REGIONAL FLOW MEASUREMENTS IN TUMORS

Award Year / Program / Phase: 2003 / SBIR / Phase II
Agency: HHS
Principal Investigator: Clyde H. Barlow
Award Amount: $716,568.00
Abstract:
DESCRIPTION (provided by applicant): In order for a tumor to grow, it must obtain nutrients and oxygen from its host and continuously evolve new vasculature to deliver supplies to its multiplying cells. Exciting current research studies of interventions that reduce or reverse malignant growth of… More

Antibody Imaging for Regional Flow Measurements

Award Year / Program / Phase: 2004 / SBIR / Phase II
Agency: HHS
Principal Investigator: Jeffrey J. Kelly
Award Amount: $750,000.00
Abstract:
DESCRIPTION (provided by applicant): This research involves the development of a method to quantify regional flow in tissues using automated instrumental procedures. Phase I results have demonstrated that fluorescent antibodies, specific to antigens in capillary endothelium, can be spatially… More

Arterial Blood Gas Measurement in Small Mammals

Award Year / Program / Phase: 2005 / SBIR / Phase I
Agency: HHS
Principal Investigator: Clyde H. Barlow
Award Amount: $100,000.00
Abstract:
DESCRIPTION (provided by applicant): In order to assure the physiological status of small experimental animals, pulmonary and circulatory functions must be monitored accurately and frequently. Arterial blood-gas measurements are critical for this monitoring, however, repeated measurements can affect… More

Intelligent Microtome Instrumentation

Award Year / Program / Phase: 2006 / SBIR / Phase I
Agency: HHS
Principal Investigator: Jeffrey J. Kelly
Award Amount: $100,000.00
Abstract:
DESCRIPTION (provided by applicant): Locating fluorescently-tagged cells in whole organisms is important to the development of gene therapy, stem cell therapy delivery methods, and for drug research. This project will develop an intelligent microtome to identify fluorescently labeled cells in whole… More

Nanocrystal Coded Microspheres for Blood Flow Measurements

Award Year / Program / Phase: 2008 / SBIR / Phase I
Agency: HHS
Principal Investigator:
Award Amount: $100,000.00
Abstract:
DESCRIPTION (provided by applicant): Regional blood flow distributions in organs of experimental animals can be measured effectively by combining fluorescent microsphere methods with imaging cryomicrotomy. The number of flow measurements that can be made i n a single animal is currently limited… More

Intelligent Microtome Instrumentation

Award Year / Program / Phase: 2009 / SBIR / Phase II
Agency: HHS
Principal Investigator: Jeffrey J. Kelly
Award Amount: $747,943.00
Abstract:
DESCRIPTION (provided by applicant): Fluorescent tagging of cells using dyes, fluorescent proteins, and quantum dots forms the basis for many powerful analytical methods in modern biology. Locating these cells within entire animals is necessary to study ce ll delivery, differentiation and gene… More

Measuring Oxygen and Hemoglobin Saturation Distributions in Skin Grafts

Award Year / Program / Phase: 2012 / SBIR / Phase I
Agency: HHS
Principal Investigator: Clyde H. Barlow – 360-867-6053
Award Amount: $150,000.00
Abstract:
DESCRIPTION (provided by applicant): This proposal outlines the development of a new product, and a new methodological approach to the simultaneous measurement of subdermal PO2 and hemoglobin oxygen saturation in skin. The product, Oxyspheres , will find wide use in the development of healing… More