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Arterial Blood Gas Measurement in Small Mammals

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
75785
Program Year/Program:
2005 / SBIR
Agency Tracking Number:
HL077006
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
BARLOW SCIENTIFIC, INC.
6307 TAMOSHAN DR NW OLYMPIA, WA 98502-
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2005
Title: Arterial Blood Gas Measurement in Small Mammals
Agency: HHS
Contract: 1R43HL077006-01A1
Award Amount: $100,000.00
 

Abstract:

DESCRIPTION (provided by applicant): In order to assure the physiological status of small experimental animals, pulmonary and circulatory functions must be monitored accurately and frequently. Arterial blood-gas measurements are critical for this monitoring, however, repeated measurements can affect blood volume and hematocrit, especially in small animals. This project will develop reagents and instrumentation to continuously monitor arterial blood gases and pH in the peripheral circulation of small mammals. Microspheres, designed to change their luminescent emission lifetimes in response to blood gases and pH, will be injected into peripheral the arterial circulation. Blood-gas parameters will be recorded by measuring lifetime changes of phosphorescent dyes in trapped microspheres. The microspheres and instrumentation developed by this project will be suitable for continuous monitoring of arterial-blood gases and pH for both acute studies and for periodic measurements of arterial-blood parameters for chronic studies lasting several months. Phase I research will develop oxygen-sensitive microspheres and will test instrumental methods to measure their phosphorescent properties in situ. The experimental success of this approach will be evaluated by measuring arterial PO2 noninvasively in the extremities of rats. Phase II research will extend the capabilities of labeled microspheres to measurements of pH and PCO2.

Principal Investigator:

Clyde H. Barlow
3608676053
CLYDE@BARLOWSCIENTIFIC.COM

Business Contact:

Mj Huetter
3608661244
MJ@BARLOWSCIENTIFIC.COM
Small Business Information at Submission:

Barlow Scientific, Inc.
Barlow Scientific, Inc. 6307 Tamoshan Dr Nw Olympia, WA 98502

EIN/Tax ID: 911468362
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No