USA flag logo/image

An Official Website of the United States Government

Monolithic Reagentless Biosensor for Online Monitoring of Waterborne Pathogens

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
89119
Program Year/Program:
2008 / SBIR
Agency Tracking Number:
ES016699
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
BIODETECTION INSTRUMENTS, LLC
535 W Research Blvd., Suite 135, M/S 300 FAYETTEVILLE, AR 72701-
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2008
Title: Monolithic Reagentless Biosensor for Online Monitoring of Waterborne Pathogens
Agency: HHS
Contract: 1R43ES016699-01
Award Amount: $100,000.00
 

Abstract:

DESCRIPTION (provided by applicant): This Small Business Innovation Research Phase I project will develop a reagentless biosensor for online monitoring of microbial contaminants in drinking water. The biosensor is based on incorporating several newly emerg ing technologies into BioDetection Instruments' proprietary sensing platform. A novel monolithic column will be developed that encapsulates a unique sensing material that can specifically and directly detect an indicator bacterium with no need for the addi tion of any reagents. The monolithic column will be characterized by a hierarchical pore structure, high surface area, small diffusion path length, and low hydraulic resistance, which are favorable for streamlining the detection efficacy. Online monitoring of microbial contamination will be realized simply by pumping or injecting the water sample through the monolithic biosensing column along with on-column optical detection. In Phase II, the research will be extended to develop a multichannel biosensor sys tem for online monitoring of multiple waterborne pathogens. The CDC reports that each year, 4 billion episodes of diarrhea result in an estimated 2 million deaths, and waterborne bacterial infections may account for as many as half of these episodes and de aths. The prevention of disease outbreaks relies on timely and efficient detection of disease-causing microorganisms. However, the detection of bacterial contaminants in drinking water still relies on cell growth-based methods, which are extremely time-con suming, typically requiring at least 24 hours and complicated multi-steps to confirm the analysis. Even current rapid methods such as ELISA and PCR still require enrichment of samples for 8-24 hours and take several hours to get only qualitative (positive/ negative) results. Part of the challenge that faces both regulatory agencies and water plants, charged with protecting public health, is to find better, cost- effective, faster technologies for rapid detection of waterborne pathogens. PUBLIC HEALTH RELEVAN CE: The proposed product will provide a reagentless assay for online monitoring of microbial contaminants in drinking water. Drinking water treatment facilities, bottled water and beverage manufacturers, as well as private well owners will benefit from the development of the proposed system. Using the proposed product, they will be able to monitor their water sources for microbial contaminations and promptly take corrective measures.

Principal Investigator:

Small Business Information at Submission:

BIODETECTION INSTRUMENTS, LLC
BIODETECTION INSTRUMENTS, LLC 535 W Research Blvd., Suite 135, M/S 300 FAYETTEVILLE, AR 72701

EIN/Tax ID: 113682219
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No