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OPTICAL RESOLUTION OF DL-PHENYLALANINE IN A MEMBRANE REACTOR

Award Information

Agency:
National Science Foundation
Branch:
N/A
Award ID:
687
Program Year/Program:
1987 / SBIR
Agency Tracking Number:
687
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
BEND RESEARCH, INC.
64550 RESEARCH RD BEND, OR 97701
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 1987
Title: OPTICAL RESOLUTION OF DL-PHENYLALANINE IN A MEMBRANE REACTOR
Agency: NSF
Contract: N/A
Award Amount: $207,000.00
 

Abstract:

PURIFICATION OF THE PRODUCTS OF AN ENZYMATIC REACTION FROM DILUTE AQUEOUS SOLUTION CAN BE ENERGY- AND EQUIPMENT- INTENSIVE. HOWEVER, TWO-LAYER MEMBRANE BIOREACTORS CONSISTING OF SANDWICHES OF PERMSELECTIVE AND IMMOBILIZED ENZYME MEMBRANES CAN BE DESIGNED TO SEPARATE AND CONCENTRATEREACTION PRODUCTS AS THEY ARE PRODUCED, THEREBY IMPROVING EFFICIENCY AND ECONOMY OF BIOCONVERSION PROCESSES. IN THE PROPOSED PROGRAM, WE WILL INVESTIGATE IMMOBILIZED-ENZYME MEMBRANE REACTORS FOR THE OPTICAL RESOLUTION OF CHEMICALLY SYNTHESIZED, RACEMIC AMINO ACID MIXTURES BASED ON REACTIONS CATALYZED BY THE ENZYMES CHYMOTRYPSIN AND AMINOACYLASE. WHEN FED A RECEIVING MIXTURE OF AN APPROPRIATE AMINO ACID DERIVATIVE, THESE MEMBRANE REACTORS WILL SIMULTANEOUSLY EFFECT THE DESIRED STEREOSPECIFIC BIOCONVERSION, CONCENTRATETHE L-ISOMER REACTION PRODUCT, AND SEPARATE IT FROM UNCONVERTED D-ISOMER. OUR OBJECTIVE IN THIS PHASE I PROGRAMIS TO DEMONSTRATE THE ABILITY OF MEMBRANE REACTORS TO PRODUCE OPTICALLY PURE L-PHENYLALANINE AND TO ESTABLISH THE SIGNIFICANCE OF PRODUCT SEPARATION AND ENRICHMENT TO PROCESSFEASIBILITY.

Principal Investigator:

Stephen L. Matson

Business Contact:

Small Business Information at Submission:

Bend Research Inc.
64550 Research Road Bend, OR 97701

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No