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DEVELOPMENT OF A LONG-ACTING DISULFIRAM

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
3337
Program Year/Program:
1986 / SBIR
Agency Tracking Number:
3337
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
BEND RESEARCH, INC.
64550 RESEARCH RD BEND, OR 97701
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 1986
Title: DEVELOPMENT OF A LONG-ACTING DISULFIRAM
Agency: HHS
Contract: N/A
Award Amount: $354,273.00
 

Abstract:

THE LONG-TERM OBJECTIVE OF THE PROPOSED PROGRAM IS TO DEVELOP A CONTROLLED-RELEASE DISULFIRAM IMPLANT FOR USE IN THE TREATMENT OF ALCOHOLISM. SPECIFIC PHASE I GOALS ARE 1. TO DESIGN CANDIDATE SYSTEMS, BASED ON TARGET PERFORMANCE TO BE DETERMINED FROM A REVIEW OF PRIOR RESEARCH, 2. TO PREPARE A SERIES OF CANDIDATE SYSTEMS, AND 3. TO DETERMINE THE IN VITRO DRUG RELEASE FROM THESE CANDIDATES. THE PROPOSED SYSTEM IS BASED ON A MEMBRANE-CONTROLLED BIOERODIBLE IMPLANT THAT WOULD DELIVER DISULFIRAM AT A CONSTANT RATE FOR SEVERAL WEEKS, RESULTING IN IMPROVED EFFICACY, GREATER PATIENT COMPLIANCE, AND FEWER SIDE EFFECTS THAN CURRENT THERAPY. SUCCESS IN THE PHASE I PROGRAM WOULD LEAD TO PROTOTYPE DEVELOPMENT, ANIMAL EFFICACY STUDIES, TOXICITY TESTING, AND FILING OF AN IND IN PHASE II FOR SUBSEQUENT HUMAN EFFICACY AND SAFETY STUDIES.

Principal Investigator:

Kelly L. Smith
Principal Investigator
5033824100

Business Contact:

Small Business Information at Submission:

Bend Research Inc.
64550 Research Rd. Bend, OR 97701

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No