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MEMBRANE-BASED THIOL/DISULFIDE EXCHANGE

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
13875
Program Year/Program:
1992 / SBIR
Agency Tracking Number:
13875
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
BEND RESEARCH, INC.
64550 RESEARCH RD BEND, OR 97701
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 1992
Title: MEMBRANE-BASED THIOL/DISULFIDE EXCHANGE
Agency: HHS
Contract: N/A
Award Amount: $470,490.00
 

Abstract:

PROTEINS ARE INCREASINGLY BEING USED AS PHARMACEUTICALS, DIAGNOSTIC AGENTS, CATALYSTS IN BIOCHEMICAL PROCESSES, AND GROWTH PROMOTERS IN MAMMALIAN CELL CULTURE. COMMERCIAL PROCESSES INVOLVING THE ISOLATION, STORAGE, AND USE OF THIOL-CONTAINING PROTEINS ARE HAMPERED BY THE LACK OF PRACTICAL PROCESSES TO MANIPULATE THE OXIDATION STATE OF PROTEIN THIOLS. ALTHOUGH PROTEIN THIOLS CAN BE MANIPULATED BY THIOL/DISULFIDE EXCHANGE, CONVENTIONAL THIOL/DISULFIDE EXCHANGE REQUIRES ADDING A STOICHIOMETRIC AMOUNT OF EXPENSIVE AND POTENTIALLY HAZARDOUS THIOL REAGENT AND IS RESTRICTED TO ONLY A FEW THIOL REAGENTS. THIS PROJECT WILL DEMONSTRATE THE FEASIBILITY OF A NOVEL METHOD TO CARRY OUT THIOL/DISULFIDE EXCHANGE THAT USES A CATALYTIC AMOUNT OF THIOL REAGENT THAT IS CONTINUOUSLY REGENERATED VIA A MEMBRANE-BASED PROCESS.

Principal Investigator:

Paul Van Eikeren
5033824100

Business Contact:

Small Business Information at Submission:

Bend Research Inc.
64550 Research Rd Bend, OR 97701

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No