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HOLLOW-FIBER DEVICE FOR REMOVING IL-1 IN HEMATOPOIESIS

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
13920
Program Year/Program:
1992 / SBIR
Agency Tracking Number:
13920
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
BEND RESEARCH, INC.
64550 RESEARCH RD BEND, OR 97701
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 1992
Title: HOLLOW-FIBER DEVICE FOR REMOVING IL-1 IN HEMATOPOIESIS
Agency: HHS
Contract: N/A
Award Amount: $498,012.00
 

Abstract:

ONE GOAL OF MEDICAL RESEARCH ON HEMATOPOIESIS-THE GROWTH AND DIFFERENTIATION OF PLURIPOTENT STEM CELLS WITHIN THE BONE MARROW-IS TO DUPLICATE THAT PROCESS IN VITRO FOR TREATMENT OF DISEASE. CURRENT METHODS ARE PLAGUED BY THE INHERENT COMPLEXITY OF THE PROCESS; FOR EXAMPLE, THE SAME GROWTH FACTORS THAT STIMULATE STEM-CELL GROWTH CAN ALSO STIMULATE UNWANTED DIFFERENTIATION. A METHOD THAT COULD REMOVE AND REPLACE SELECTED GROWTH FACTORS WOULD BE INVALUABLE TO THE PRACTICAL USE OF IN VITRO HEMATOPOIESIS. BEND RESEARCH, INC., PLANS TO DEVELOP A HOLLOW-FIBER MEMBRANE ADSORBENT (HFMA) THAT SELECTIVELY REMOVES HEMATOPOIETIC GROWTH FACTORS. IN PHASE I, THE FEASIBILITY OF THE CONCEPT WILL BE TESTED BY REMOVING INTERLEUKIN-1 (IL-1) FROM STEM-CELL CULTURE MEDIUM USING ANTIBODIES FOR IL-1 IMMOBILIZED IN THE PORES OF THE HOLLOW FIBERS. IN PHASE II, AN ENTIRE STEM-CELL CULTURE SYSTEM IN WHICH THE HFMAS WOULD CONTROL THE REMOVAL AND ADDITION OF SPECIFICGROWTH FACTORS WILL BE DEVELOPED. ULTIMATELY, THIS COULD LEAD TO COMMERCIALIZATION OF A SYSTEM FOR GROWING EITHER STEM CELLS OR SPECIFIC BLOOD-CELL LINEAGES FOR SUCH THERAPIES AS STEM-CELL REPLACEMENT IN CANCER TREATMENT OR TREATMENT OF IMMUNODEFICIENCY DISORDERS.

Principal Investigator:

Paul Van Eikeren
5033824100

Business Contact:

Small Business Information at Submission:

Bend Research Inc.
64550 Research Rd Bend, OR 97701

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No