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A HIGHLY SELECTIVE PROCESS FOR SEPARATING ENANTIOMERS

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
14042
Program Year/Program:
1990 / SBIR
Agency Tracking Number:
14042
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
BEND RESEARCH, INC.
64550 RESEARCH RD BEND, OR 97701
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1990
Title: A HIGHLY SELECTIVE PROCESS FOR SEPARATING ENANTIOMERS
Agency: HHS
Contract: N/A
Award Amount: $49,926.00
 

Abstract:

THIS WORK IS DIRECTED TOWARD THE INVESTIGATION OF A NEW MEMBRANE-BASED PROCESS FOR THE SEPARATION OF ENANTIOMERS IN A RACEMIC MIXTURE. MANY BIOLOGICALLY ACTIVE SUBSTANCES ARE CHIRAL, AND IN GENERAL ONLY ONE OF THE ENANTIOMERS IN THE RACEMIC MIXTURE PRODUCES THE DESIRED BIOLOGICAL ACTIVITY. FREQUENTLY, THE UNWANTED ENANTIOMER INHIBITS THE DESIRED BIOLOGICAL ACTIVITY OF THE ACTIVE ENANTIOMER AND/OR EXHIBITSUNDESIRABLE SIDE EFFECTS. THE BEST CURRENTLY AVAILABLE ENANTIOMER RESOLUTION SCHEMES (E.G., FRACTIONAL CRYSTALLIZATION AND CHIRAL CHROMATOGRAPHY)HAVE A NUMBER OF DRAWBACKS, INCLUDING THE FOLLOWING: (1) THEY HAVE LOW RESOLUTION, PARTICULARLY WHEN SCALED UP TO A PRACTICAL SIZE; (2) THEY ARE LABOR INTENSIVE; AND (3) THEY ARE DIFFICULT TO OPERATE CONTINUOUSLY. THE NEW MEMBRANE-BASED PROCESS FOR ENANTIOMER RESOLUTION EMPLOYS A MOBILE CARRIER IN A LIQUID-MEMBRANE OPERATION. DURING PHASE I, THE FEASIBILITY OF THE PROCESS FOR THE ISOLATION OF D-PROPRANOLOL, AN IMPORTANT BETA-BLOCKER DRUG, FROM A RACEMIC MIXTURE OF D,L-PROPRANOLOL WILL BE DEMONSTRATED.

Principal Investigator:

Paul Van Eikeren
5033824100

Business Contact:

Small Business Information at Submission:

Bend Research Inc
64550 Research Rd Bend, OR 97701

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No