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Novel Absorbent for Efficient Enantiomer Separation

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
25102
Program Year/Program:
1994 / SBIR
Agency Tracking Number:
25102
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
BEND RESEARCH, INC.
64550 RESEARCH RD BEND, OR 97701
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1994
Title: Novel Absorbent for Efficient Enantiomer Separation
Agency: HHS
Contract: 1 R43 GM50656-1,
Award Amount: $77,767.00
 

Abstract:

Chiral drugs, when administered in enathiomerically pure form, offer significant clinicaladvantages over their racemic counterparts. However, available methods for chiral resolution of racemiccompounds, such as diasteriomeric derivatization and chiral chromatography, have drawbacks, includinghigh cost, difficulty with scale-up and lack of applicability for many chiral compounds. This project isdirected toward demonstrating the feasibility of an economical, large-scale chromatographic process forthe chiral resolution of a broad range of racemic compounds. The main focus of this program will bethe development of a single, representative chromatographic medium suitable for use in the process.This novel medium will be packed into a highly efficient column and used to resolve three pharmacologi-cally relevant drugs on a laboratory scale. This Phase I program has three objectives: 1) to demonstratethat the process is technical feasible, 2) to demonstrate that the process can resolve three racemic drugsto enantiomeric purity suitable for pharmaceutical use, and 3) to demonstrate that the process promisesto be economical. Success in Phase I would lead to Phase II proposal focusing on expanding thetechnology to a wide range of chiral compounds, developing strategies for optimization, identifyingscale-up issues, validating the process on a larger scale, and completing a detailed economic analysis.

Principal Investigator:

James West
5033824100

Business Contact:

Small Business Information at Submission:

Bend Research, Inc.
64550 Research Road Bend, OR 97701

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No