Mercury Fiber Electrode for Determining Lead in Blood
1 R43 ES06991-1,
Childhood lead poisoning is stated to be "the nation's leading childhood environmental disease"and being able to accurately determine toxic lead concentrations from small volumes of children's bloodin an accurate and cost effective manner is a considerable challenge. This research describes a novelmercury fiber electrode that maintains the advantages of mercury as an electrode material and eliminatesthe problems associated with measurement in biological samples. This design places mercury inside asmall diameter dialysis tube which can be directly dipped into a sample or it can be put in a flow streamfor on line detection. The aims of this proposal is to characterize this electrode's performance; detectionlimits, precision and linearity of the lead ion response in the presence of interfering substances foundin blood samples such as proteins and oxygen. The results of this research could lead to a portable,automated analyzer that could be used in the field or laboratory. In addition, many procedures have beendeveloped using mercury electrodes and the analyzer could also be used to determine lead and othermetals from environmental samples. The design also may have applications as a detector for liquidchromatographs for the determination of difficult to reduce substances.
Small Business Information at Submission:
Principal Investigator:Craig Brunlett
Bioanalytical Systems, Inc.
2701 Kent Avenue West Lafayette, IN 47906
Number of Employees: