Producing erythropoietin from human kidney cells in culture.at present, the only commercially available source of human erythropoietin is from the urine of aplastic anemics. humancells in culture represents an excellent alternative source for human erythropoietin. if erythropoietin can be… More

The purpose of this phase i proposal is to develop a mammalian cell culture aneuploidy assay using the cak mouse cell line. while a great number of short term assays have been developed to detect compounds which induce either gene mutations or chromosomal damage, little research has focusedon the… More

Extracellular-signal-regulated kinase (ERK) is a key protein kinase of the MAP kinase pathway and plays a key role in cell proliferation, differentiation and migration. The MAPK cascade presents many targets for the development of novel and safer cancer th erapies. Despite a lot of progress in the… More

AMP-activated protein kinase (AMPK) is a serine/threonine kinase that is a member of a metabolite sensing protein kinase family. AMPK is involved in controlling cellular metabolism and cell proliferation and when activated has been found to be a potent tum or suppressor. Despite a lot of progress in… More

The Contractor will develop pharmacodynamic assays for measuring a number of high-priority molecular targets. These assays will be suitable for pre-clinical and clinical testing to allow for rapid evaluation of treatment responses, gauge treatment correspondence to tumor stasis/regression, allow… More