USA flag logo/image

An Official Website of the United States Government

Non-invasive Assessment of Insulin Resistance

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
76178
Program Year/Program:
2005 / SBIR
Agency Tracking Number:
DK072637
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
BIOCHEMANALYSIS CORPORATION
2201 W CAMPBELL PARK DR Suite 28 CHICAGO, IL -
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2005
Title: Non-invasive Assessment of Insulin Resistance
Agency: HHS
Contract: 1R43DK072637-01
Award Amount: $202,652.00
 

Abstract:

DESCRIPTION (provided by applicant): The long-term objectives of this project are to develop a novel non-invasive test of insulin resistance. The proposed test is based on the well-established principle of inverse relationship between glucose oxidation (Gox) and lipid oxidation (Lox) during cellular respiration. Because the ratio of whole-body Gox/Lox can be measured precisely after administration of a standard dose of 13C-glucose as part of an oral glucose tolerance test (OGTT) based on isotopic analyses of breath CO2, we propose that a suitable noninvasive test of insulin resistance can be developed. During Phase-I, we propose to conduct a limited clinical protocol in individuals who vary across a range of insulin resistance, in order to demonstrate the expected inverse relationship between the proposed test and the currently most useful clinical test of insulin resistance; viz., the whole-body insulin sensitivity index (WBISI). During Phase-H, we will conduct a number of clinical protocols designed specifically to examine the impact of potentially important parameters (experimental and physiological) on performance parameters of this test. We expect that successful completion of research proposed for Phase-I and Phase-H leads to a proprietary product-method specifically for non-invasive assessment of insulin resistance.

Principal Investigator:

Morteza Janghorbani
3122435988
MJANGHOR@SBCGLOBAL.NET

Business Contact:

Dorothy Cribbs
3122435988
DCRIBBS@ISERV.NET
Small Business Information at Submission:

Biochemanalysis Corporation
Biochemanalysis Corporation 2201 W Campbell Park Dr Chicago, IL 60612

EIN/Tax ID: 363801900
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No