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Triple Helix-Based Acoustic Plate Mode DNA Biosensor

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
22261
Program Year/Program:
1993 / SBIR
Agency Tracking Number:
22261
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
BIODE, INC.
2 OAKWOOD RD CAPE ELIZABETH, ME 04107
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1993
Title: Triple Helix-Based Acoustic Plate Mode DNA Biosensor
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

BIODE will utilize the results of its Phase I research to develop (Phase II) and commercialize (Phase III) a totally new solid state biosensor technology for biological measurements. This technology is based upon the merging of two technologies: Triple Helix Nucleic Acid Probes with Acoustic Plate Mode (APM) micro sensors. Recent advances by BIODE in the design and operation of APM devices have resulted in a DNA hybridization sensor principle with excellent sensitivity (nanograms/milliliter), selectivity and temperature stability when used with a model probe system. BIODE has received further funding from the DOE to optimize the electrical properties of the device. We will also attempt the direct electronic in situ sensing of a diagnostically significant DNA gene sequence, which codes for the abundant late matrix antigen of Cytomegalovirus. A known short-coming of the previous work is the need to denature naturally-occurring dsDNA to single strands before the sensor is able to detect it. The current project addresses the issue of dsDNA detection via triple helix capture. The currently-funded DOE contract will provide BIODE with an extremely sensitive detection element, and the work will provide an improved technique for imparting selectivity to the device.

Principal Investigator:

Douglas J. McAllister
2078831492

Business Contact:

Small Business Information at Submission:

Biode Inc.
2 Oakwood Road Cape Elizabeth, ME 04107

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No