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THE CAUSATIVE AGENT OF THE ACQUIRED IMMUNE DEFICIENCY SYNDROME (AIDS), AN…

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
4686
Program Year/Program:
1986 / SBIR
Agency Tracking Number:
4686
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Biogen Research Corp
14 Cambridge Center Cambridge, MA 02142
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1986
Title: THE CAUSATIVE AGENT OF THE ACQUIRED IMMUNE DEFICIENCY SYNDROME (AIDS), AN INEVITABLY FATAL DISEASE, APPEARS TO BE A MEMBER OF A CLOSELY RELATED FAMILY OF RNA VIRUSES CALLED HUMAN T-LYMPHOTROPIC VIRUS TYPE III (HTLV-III) OR LYMPHADENOPATHY-ASSOCIATED
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

THE CAUSATIVE AGENT OF THE ACQUIRED IMMUNE DEFICIENCY SYNDROME (AIDS), AN INEVITABLY FATAL DISEASE, APPEARS TO BE A MEMBER OF A CLOSELY RELATED FAMILY OF RNA VIRUSES CALLED HUMAN T-LYMPHOTROPIC VIRUS TYPE III (HTLV-III) OR LYMPHADENOPATHY-ASSOCIATED VIRUS (LAV). THE HOST RANGE OF THIS VIRUS IS DEFINED BY CELLS WHICH BEAR THE SURFACE GLYCOPROTEIN T4. INDEED, ALL AVAILABLE EVIDENCE INDICATES THAT T4 IS THE MEMBRANE-ANCHORED RECEPTOR FOR HTLV-III/LAV. CLINICAL STUDIES SUGGEST THAT THE PROGRESSION OF DISEASE CAN BE CORRELATED WITH DEPLETION OF A FUNCTIONAL CLASS OF IMMUNE SYSTEM REGULATORY CELLS, T-HELPER LYMPHOCYTES, WHICH DISPLAY THE T4 SURFACE PROTEIN AND THAT THIS T-CELL DEPLETION, WITH ENSUING IMMUNOLOGICAL COMPROMISE, MIGHT RESULT FROM RECURRENT CYCLES OF INFECTION AND LYTIC GROWTH. THIS SUGGESTS A THERAPEUTIC STRATEGY FOR THE TREATMENT OF AIDS AND PRE-AIDS: RECOMBINANT SOLUBLE T4 PROTEIN WILL SERVTO SEQUESTER FREE HTLV-III/LAV BY ACTING AS SOLUBLE VIRUS RECEPTOR. THIS WILL IN TURN RETARD OF COMPLETELY INHIBIT VIRUS GROWTH IN INFECTED INDIVIDUALS.

Principal Investigator:

Richard a fisher
PRINCIPAL INVESTIGATOR
6178648900

Business Contact:

Small Business Information at Submission:

Biogen Research Corp
14 Cambridge Center Cambridge, MA 02142

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No