System to Test Medications Developed to Treat Drug Abuse
DESCRIPTION (Applicant's Abstract): The goal of this project is to create a system to test potential therapeutic medications for substance abuse.
Information on the neurophysiology of the sites of drug action in the brain
reward circuitry in animal models is critical for understanding the process of
addiction in brain and clarifying modes of therapeutic intervention designed to
block the craving and negative brain affect and mood characteristics of the
addiction process. The new technology will build on significant new advances in
fabrication of recording probes, which have recently made possible the
recording of impulse trains from large populations of single neurons in animal
models of addiction to drugs. One goal is to produce an advanced real time
software module for the Windows 2000 operating system capable of controlling
multiple behavioral chambers for testing potential medications for substance
abuse. A further aim will be to create a relational database for organizing the
control of experiments and accumulating all relevant experimental data. A
Website interface with JAVA- language active-server applications will enable
access to data in real time at remote sites on the Internet. An existing
software and hardware system for capturing data from multiple spike trains will
be significantly enhanced, redesigned, and greatly reduced in cost to allow
automated sorting and time stamping of waveforms from large populations of
neurons in the mesolimbic "brain reward system" during drug self administration
behavior. The goal is to allow neuron population recording to be achieved
routinely during studies of behavioral actions of candidate drug medications.
Technology developed will be used applications throughout basic and clinical
neurophysiology, including real time control of prosthetic robotics devices.
This project will lead to establishment of new procedures urgently needed for
evaluating efficacy and mode of action of therapeutic drugs for substance
PROPOSED COMMERCIAL APPLICATION:
This multichannel software/hardware data acquisition system will allow a new mode of testing of potential medication for substance abuse. The system is equally adapted to a wide range off application in clinical neuroscience and physiological study. The ability to acquire multichannel neuron activity is managed by a real time software module that is readily adapted to robotic control of prosthetic devices.
Small Business Information at Submission:
Principal Investigator:James S. Campbell
2000 W 1ST ST, STE 406 WINSTON-SALEM, NC 27104
Number of Employees: