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REGULATION OF BIOLOGICAL GROWTH

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
4833
Program Year/Program:
1987 / SBIR
Agency Tracking Number:
4833
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Biogrowth Inc.
3065 Atlas Road Suite 117 Richmond, CA 94806
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 1987
Title: REGULATION OF BIOLOGICAL GROWTH
Agency: HHS
Contract: N/A
Award Amount: $500,000.00
 

Abstract:

THE LONG-TERM OBJECTIVE OF THIS PROJECT IS TO BE ABLE TO REGULATE ABNORMAL GROWTH PROCESSES THAT ARE RELATED TO SOMATOMEDINS. AS SOMATOMEDINS ARE THE MAJOR STIMULATORS OF BONE FORMATION, THEY OFFER PROMISE IN THE THERAPY OF POST- MENOPAUSAL OSTEOPOROSIS. THEY MAY ALSO BE USED TO STIMULATEBONE FORMATION AROUND PROSTHETIC JOINTS. THE STIMULATORY PROPERTIES OF SOMATOMEDINS MAY ALSO BE IMPORTANT IN HASTENING A WOUND HEALING. BECAUSE OF THEIR SHORT HALF- LIFE, THE SOMATOMEDINS REQUIRE DEVELOPMENT OF AN APPROPRIATEDELIVERY SYSTEM. AS THEY ARE TRANSPORTED IN PLASMA BOUND TOA CARRIER PROTEIN, THE LATTER WILL BE UTILIZED. SINCE THIS PROTEIN BLOCKS THE GROWTH PROMOTING EFFECTS OF SOMATOMEDIN, IT WILL ALSO BE USEFUL FOR SUPPRESSING THE GROWTH OF THOSE TUMORS THAT PRODUCE SOMATOMEDIN AND AUTOSTIMULATE THEIR OWN GROWTH. THE SPECIFIC AIMS OF THIS PROJECT WILL BE TO PURIFYTO HOMOGENEITY THE HUMAN SERUM CARRIER PROTEIN, CHARACTERIZEIT, AND PRODUCE ANTIBODIES TO IT.

Principal Investigator:

E Martin Spencer
Principal Investigator
0

Business Contact:

Small Business Information at Submission:

Biogrowth Inc.
505 Ortega Street San Francisco, CA 94122

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No