Chemical synthesis of 50-500 gram quantities of oligonucleotides which can be utilized for antisense-dna therapeutics and diagnostics. the research objectives are to investigage improved chemistries, to assemble a manual device which will utilize solid-phase cyanothyl phosphoramidite or phosphonate… More

Not Available There is a need for Spatial Light Modulators (SLM)'s that have a few nanometers phase resolution' have > 128X128 pixels, are fast (>500 Hz), have at least 2-pi range of modulation, and have continuous phase capability. Devices of this type would have applications in the areas of… More

DESCRIPTION (Applicant's abstract): In Phase I Research, a pressurized gas thermocycler was fabricated and successfully used to amplify gene fragments from human beta-globin (536 b.p.), Human Platelet Antigen (364 b.p.), bacteriophage lambda (333 b.p.), and a… More

DESCRIPTION (Applicant's abstract): In Phase I Research, a pressurized gas thermocycler was fabricated and successfully used to amplify gene fragments from human beta-globin (536 b.p.), Human Platelet Antigen (364 b.p.), bacteriophage lambda (333 b.p.), and a… More

DESCRIPTION (provided by applicant): Thermolabile protecting groups of nucleic acids which can be removed during genomic methods will be developed. Protecting groups for nucleobase substituents involved in Watson-Crick hydrogen bonding will be identified and used to block hybridization. Subsequent… More

DESCRIPTION (provided by applicant): The purification of large biomolecules is an important component of biological research and for the production of recombinant proteins that are being utilized for numerous applications in medicine. The conventional chromatographic media used for this purpose have… More

DESCRIPTION (provided by applicant): This project is focused on the development of a new type of chromatographic medium prepared by applying very thin polymeric coatings onto non-woven fabrics and having ion exchange groups suitable for adsorption and purification of large biomolecules. The… More

DESCRIPTION (provided by applicant): The goal of this project is to develop advanced ultrafiltration (UF) devices for sample preparation that are faster and easier to use than existing devices. New technology based on proprietary concepts enables ultrafilt ration to be practiced at low pressure, and… More

DESCRIPTION (provided by applicant): The objective of this work is to develop new manufacturing technology for large-scale production of recombinant proteins. Purification technology for large biomolecules such as monoclonal antibodies is an important component of biological research and for the… More