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RAPID, ACCURATE IDENTIFICATION OF YEASTS

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
7890
Program Year/Program:
1990 / SBIR
Agency Tracking Number:
7890
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
BIOLOG, INC.
21124 CABOT BLVD. HAYWARD, CA 94545
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 1990
Title: RAPID, ACCURATE IDENTIFICATION OF YEASTS
Agency: HHS
Contract: N/A
Award Amount: $500,000.00
 

Abstract:

THE INCIDENCE OF INFECTIONS CAUSED BY YEASTS HAS INCREASED IN RECENT YEARS DUE TO INCREASES IN THE NUMBER OF IMMUNO-COMPROMISED PATIENTS (E.G. AIDS). BECAUSE YEASTS GROW SLOWLY, IT IS DIFFICULT BUT IMPORTANT TO DEVELOP RAPID METHODS FOR THEIR IDENTIFICATION. BIOLOG HOLDS TWO PATENTS ON A NEW REDOX METHOD WHICH IDENTIFIES AN ORGANISM BASED ON PATTERNS OF CARBON SOURCE UTILIZATION. THE METHOD EMPLOYS A TETRAZOLIUM DYE TO COLORIMETRICALLY INDICATE CARBON SOURCE OXIDATIONS. PRINCIPAL ADVANTAGES OF THE METHOD ARE: (1)SPEED--FOR MOST MICROORGANISMS TESTS CAN BE COMPLETED IN UNDER 4 HOURS, (2) SIMPLICITY--THIS IS AN EASY TO INOCULATE AND READ SINGLE COLOR CHEMISTRY, AND (3) ACCURACY--DRAWING FROM THOUSANDS OF POTENTIAL CARBON SOURCESSHOULD ENABLE US TO DEVELOP A TEST PANEL THAT IS FAR MORE ACCURATE THAN ANYTHING PRESENTLY AVAILABLE. THIS PHASE I STUDY WILL DEMONSTRATE THE FEASIBILITY OF DEVELOPING A RAPID AND ACCURATE SPECIATION KIT FOR YEASTS. TWO TASKS ARE INVOLVED: (1) THE DEVELOPMENT OF A SUSPENSION MEDIUM COMPATIBLE WITH THE REDOX CHEMISTRY WHICH IS TAILOREDTO THIS DIVERSE GROUP OF YEASTS, AND (2) A SURVEY OF 380 POTENTIAL TEST SUBSTRATES TO DEMONSTRATE THAT NEW AND USEFUL SPECIATION TESTS CAN BE FOUND BASED ON CARBON SOURCE OXIDATION REACTIONS. THE POTENTIAL MARKET FOR THESE KITS ISLARGE, AND INCLUDES HOSPITAL, PUBLIC HEALTH, AND CLINICAL LABORATORIES.

Principal Investigator:


0

Business Contact:

Small Business Information at Submission:

Biolog Inc.
3447 Investment Blvd Ste 3 Hayward, CA 94545

EIN/Tax ID:
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No