This phase i, 6-month feasibility study is to address problems outlined by the fundamental neurosciences program of the national institute of neurological and communicative disorders and stroke (nincds). ultimate long term success of an auditory prosthesis requires an electrode design whichis… More

Two main areas must be studied to develop a suitable small diameter vascular graft: improvement in material blood compatibility and development of a compliant graft which matches that of the natural vessel. this phase i sbir proposal will only address the blood compatibility question and will… More

Urinary tract infections associated with urinary drainage catheters are a significant clinical problem resulting in a prolonged hospital stay and an increased mortality risk. this proposal addresses a feasibility study to determine if surface modification of the catheter will inhibit bacterial… More

A treatment of hydrophilic poly(hydroxyethyl methacrylate) contact lenses to minimize irreversible protein adsorption will be tested. protein adsorption on lenses not only leads to clouding and opacities, but also induces what appears to be an immune response in the wearer. this response is observed… More

Since antigens released from tumor cells can thwart the host's immune reactivity against immunogenic tumors in favor of tumor growth, the present work proposes to develop an extracorporeal system to remove the tumor antigen as well as the bound antigen (antigen-antibody complex) from the patient's… More

A need exists for cheap, simple, sensitive, and rapid nonisotopic immunoassays for the detection of pathogenic viruses, bacteria, and cells. development of an interfacial light-scattering immunoassay (isi) is proposed. surface immobilized antibodies provide target organism specificity while total… More

This project addresses the development and evaluation of a prototype laser raman scattering gas sensor. potential application areas are: blood po2/pco2 via suitable sampling catheter and noninvasive monitoring of respiration, anesthesia delivery, lung function, and cardiac output. mass spec, while… More

A need exists to quantitate anesthetic and respiratory gases(o2, co2, n2) in the operating room. previous work has shown that raman light scattering can be successfully utilized for molecular gas analysis. the raman signal for each gas can be separated from the laser beam rayleigh scatter via filter… More

The development of a fiberoptic ph probe is proposed using a fluorescent dye immobilized in a hydrophilic gel matrix. the main tasks in this project are: (1) set-up of research instrumentation for measuring and characterizing experimental probes, (2) selection and immobilization of dyes at the tip… More

The anticoagulant, heparin, will be derivatized with biologically compatible hydrophobic macromolecules to make them water insoluble. this derivatization will occur through hydrophilic spacer groups, allowing the heparin to extend into the aqueous environment and retain its bioactive configuration.… More

Using the mouse peritoneal implant model, materials will be evaluated for their biocompatibility. the objective of thisstudy will be to develop materials with minimal tendency forcellular and tissue adhesion. polyurethanes and silicones, materials widely used in biomedical device fabrication, willbe… More