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TWO MAIN AREAS MUST BE STUDIED TO DEVELOP A SUITABLE SMALL DIAMETER VASCULAR…

Award Information

Agency:
National Science Foundation
Branch:
N/A
Award ID:
1585
Program Year/Program:
1984 / SBIR
Agency Tracking Number:
1585
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Biomaterials International Inc
420 Chipeta Way Suite 160 Salt Lake City, UT 84108
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1984
Title: TWO MAIN AREAS MUST BE STUDIED TO DEVELOP A SUITABLE SMALL DIAMETER VASCULAR GRAFT: IMPROVEMENT IN MATERIAL BLOOD COMPATIBILITY AND DEVELOPMENT OF A COMPLIANT GRAFT WHICH MATCHES THAT OF THE NATURAL VESSEL.
Agency: NSF
Contract: N/A
Award Amount: $40,000.00
 

Abstract:

TWO MAIN AREAS MUST BE STUDIED TO DEVELOP A SUITABLE SMALL DIAMETER VASCULAR GRAFT: IMPROVEMENT IN MATERIAL BLOOD COMPATIBILITY AND DEVELOPMENT OF A COMPLIANT GRAFT WHICH MATCHES THAT OF THE NATURAL VESSEL. THIS PHASE I SBIR PROPOSAL WILL ONLY ADDRESS THE BLOOD COMPATIBILITY QUESTION AND WILL COMPARE A POLYMER COATED WOVEN DACRON GRAFT AGAINST CONTROL GRAFT MATERIALS OF UNCOATED DACRON AND EXPANDED POLYTETRAFLUOROETHYLENE (E-PTFE). THIS POLYMER COATING HAS BEEN SHOWN TO EXHIBIT GOOD BLOOD COMPATIBILITY FROM PRELIMINARY IN VITRO STUDIES. GRAFT DIAMETERS OF 4 MM WILL BE STUDIED IN VIVO USING DOGS AS THE EXPERIMENTAL ANIMAL MODEL. SIX ANIMALS WILL BE TESTED USING A TOTAL OF 24 GRAFTS (4 PER ANIMAL). BEFORE IMPLANTATION, ALL MATERIALS WILL BE WELL CHARACTERIZED BOTH FOR BULK AND SURFACE PROPERTIES. THE PATENCY OF THE GRAFTS WILL BE CHECKED DAILY BY PALPITATION AND BY TRANSCUTANEOUS APPLICATION OF A DOPPLER FLOWMETER. AFTER EIGHT WEEKS, THE GRAFTS WILL BE RETRIEVED AND ANALYZED USING A WELL DEFINED PROTOCOL. IF THE COATED GRAFTS PROVE SUPERIOR TO THE CONTROL GRAFTS, PHASE II STUDIES WILL ADDRESS THIS COATING PROCESS OVER A SUBSTRATE WHICH MATCHES THE COMPLIANCE OF THE NATURAL VESSEL.

Principal Investigator:

Donald e. gregonis
DIRECTOR
0

Business Contact:

Donald E. Gregonis
Director Polymer & Synthetic
Small Business Information at Submission:

Biomaterials International Inc
P.o. Box 8852 Salt Lake City, UT 84108

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No