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SINCE ANTIGENS RELEASED FROM TUMOR CELLS CAN THWART THE HOST'S IMMUNE…

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
2977
Program Year/Program:
1985 / SBIR
Agency Tracking Number:
2977
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Biomaterials International Inc
420 Chipeta Way Suite 160 Salt Lake City, UT 84108
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1985
Title: SINCE ANTIGENS RELEASED FROM TUMOR CELLS CAN THWART THE HOST'S IMMUNE REACTIVITY AGAINST IMMUNOGENIC TUMORS IN FAVOR OF TUMOR GROWTH, THE PRESENT WORK PROPOSES TO DEVELOP AN EXTRACORPOREAL SYSTEM TO REMOVE THE TUMOR ANTIGEN AS WELL AS THE BOUND ANTIGEN
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

SINCE ANTIGENS RELEASED FROM TUMOR CELLS CAN THWART THE HOST'S IMMUNE REACTIVITY AGAINST IMMUNOGENIC TUMORS IN FAVOR OF TUMOR GROWTH, THE PRESENT WORK PROPOSES TO DEVELOP AN EXTRACORPOREAL SYSTEM TO REMOVE THE TUMOR ANTIGEN AS WELL AS THE BOUND ANTIGEN (ANTIGEN-ANTIBODY COMPLEX) FROM THE PATIENT'S PLASMA AND RETURN HIS/HER OWN PURIFIED PLASMA TO THE PATIENT. THE FIRST PHASE OF THE PROPOSED WORK INVOLVES IN VITRO STUDIES ON THE EFFICIENCY OF SEPARATION OF TUMOR ANTIGEN FROM THE PLASMA OF A BREAST CANCER PATIENT AND ITS EFFECT ON THE LYMPHOCYTE CYTOTOXICITY. THE PROCESS OF SEPARATION OF TUMOR ANTIGEN FROM PLASMA INVOLVES THREE STEPS: A.DISSOCIATION OF IMMUNE COMPLEXES AT PH 3.1 B.SEPARATION OF TUMOR ANTIGEN BY ULTRAFILTRATION. C.READJUSTMENT OF PLASMA PH BY DIALYSIS. IN VITRO STUDIES ARE PLANNED I.TO DESIGN AND DEVELOP THIS SYSTEM TO PROCESS THE PLASMA FROM A CANCER PATIENT, AND II.TO DETERMINE THE CHANGE IN LYMPHOCYTE CYTOTOXICITY

Principal Investigator:

Donald e. gregonis
PRINCIPAL INVESTIGATOR
8015838444

Business Contact:

Small Business Information at Submission:

Biomaterials International Inc
P.o. Box 8852 Salt Lake City, UT 84108

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No