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A NEED EXISTS FOR CHEAP, SIMPLE, SENSITIVE, AND RAPID NONISOTOPIC IMMUNOASSAYS…

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
2904
Program Year/Program:
1985 / SBIR
Agency Tracking Number:
2904
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Biomaterials International Inc
420 Chipeta Way Suite 160 Salt Lake City, UT 84108
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1985
Title: A NEED EXISTS FOR CHEAP, SIMPLE, SENSITIVE, AND RAPID NONISOTOPIC IMMUNOASSAYS FOR THE DETECTION OF PATHOGENIC VIRUSES, BACTERIA, AND CELLS.
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

A NEED EXISTS FOR CHEAP, SIMPLE, SENSITIVE, AND RAPID NONISOTOPIC IMMUNOASSAYS FOR THE DETECTION OF PATHOGENIC VIRUSES, BACTERIA, AND CELLS. DEVELOPMENT OF AN INTERFACIAL LIGHT-SCATTERING IMMUNOASSAY (ISI) IS PROPOSED. SURFACE IMMOBILIZED ANTIBODIES PROVIDE TARGET ORGANISM SPECIFICITY WHILE TOTAL INTERNAL REFLECTION-GENERATED INTERFACIAL LIGHT SCATTERING PROVIDES INTENSE, TARGET-SPECIFIC SIGNAL. SPECIFIC AIMS ARE: 1.DETERMINATION OF DETECTABILITY LIMITS, DYNAMIC RANGE AND RESPONSE TIME FOR MAMMALIAN ERYTHROCYTES, STREPTOCOCCUS B, AND ADENOVIRUS, 2.BINDING EFFICACY OF MONOCLONAL VERSUS POLYCLONAL ANTIBODY WILL BE COMPARED, A.PASSIVE ADSORPTION ON HYDROPHILIC QUARTZ AND ON HYDROPHOBIC 3-AMINOPROPYL TRIETHOXYSILANE (APS)-QUARTZ, AND COVALENT BONDING TO B.APS-QUARTZ VIA GLUTARALDEHYDE AND C.QUARTZ-APS-HYDROGEL, 4.NONSPECIFIC TARGET ORGANISM BINDING AND ITS MINIMIZATION VIA HYDROGEL SURFACE DERIVATIZATION WILL BE EVALUATED, AND 5.TO DESIGN, CONSTRUCT, AND EVALUATE A PROTOTYPE IMMUNOASSAY INSTRUMENT BASED UPON SMALL, DISPOSABLE, INTERNAL REFLECTION ELEMENT SAMPLE PLATES. PHASE I SHOULD PROVE CONCEPT FEASIBILITY^EXCELLENT DETECTION LIMITS FOR A WIDE VARIETY AND SIZE RANGE OF MICRO-ORGANISMS. HYDROGEL SURFACES SHOULD MINIMIZE NONSPECIFIC ADSORPTION OF ORGANISMS AND THE PROTOTYPE SHOULD BE DESIRABLE FOR USE IN CLINICS, HOSPITALS, AND DOCTORS' OFFICES.

Principal Investigator:

Richard a. van wagenen
PRINCIPAL INVESTIGATOR
8015838444

Business Contact:

Small Business Information at Submission:

Biomaterials International Inc
420 Chipeta Way, Suite #160 Salt Lake City, UT 84108

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No