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HEPARIN ADSORPTION COMPLEXES FOR BLOOD COMPATIBILITY

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
7310
Program Year/Program:
1987 / SBIR
Agency Tracking Number:
7310
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Biomaterials International Inc
420 Chipeta Way Suite 160 Salt Lake City, UT 84108
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1987
Title: HEPARIN ADSORPTION COMPLEXES FOR BLOOD COMPATIBILITY
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

THE ANTICOAGULANT, HEPARIN, WILL BE DERIVATIZED WITH BIOLOGICALLY COMPATIBLE HYDROPHOBIC MACROMOLECULES TO MAKE THEM WATER INSOLUBLE. THIS DERIVATIZATION WILL OCCUR THROUGH HYDROPHILIC SPACER GROUPS, ALLOWING THE HEPARIN TO EXTEND INTO THE AQUEOUS ENVIRONMENT AND RETAIN ITS BIOACTIVE CONFIGURATION. THESE HEPARIN DERIVATIVES WILL BE SOLVENT-COATED ONTO BIOMEDICAL DEVICES TO PROVIDE LOW-COST, IMMOBILIZED HEPARIN SURFACES APPLICABLE TO ESSENTIALLY ALL TYPES OF POLYMERS USED FOR CATHETERS, TUBING, MEMBRANE OXYGENATORS, ETC. THIS PHASE I PROPOSAL ADDRESSES THE HEPARIN DERIVATIZATION, ADSORPTION STABILITY, TOXICITY, AND BIOLOGICAL EFFECTIVENESS OF THE ADSORPTION COMPLEXES ON SURFACES. LONG-TERM GOALS IN PHASE II INCLUDE SPECIFICALLY TAILORING HIGH MOLECULAR WEIGHT MOLECULES TO BIND TO HEPARIN SO THAT FEWER MOLECULES WOULD NEED TO BE BOUND TO IMMOBILIZE HEPARINTO THE SURFACE. RADIOLABELED EXPERIMENTS WILL BE DONE TO VERIFY THAT NO MODIFIED HEPARIN MOLECULES WILL DESORB IN THE BLOOD ENVIRONMENT. IN VIVO ANIMAL STUDIES WILL BE DONE TO SHOW THE EFFECTIVENESS OF THE IMMOBILIZED HEPARIN IN BOTH ACUTE AND LONG-TERM APPLICATIONS.

Principal Investigator:

Donald e gregonis phd
8015838444

Business Contact:

Small Business Information at Submission:

Biomaterials International Inc
420 Chipeta Way Suite 160 Salt Lake City, UT 84108

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No