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POLYMERIC MATERIALS TO MINIMIZE CELL AND TISSUE ADHESION

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
7270
Program Year/Program:
1987 / SBIR
Agency Tracking Number:
7270
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Biomaterials International Inc
420 Chipeta Way Suite 160 Salt Lake City, UT 84108
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1987
Title: POLYMERIC MATERIALS TO MINIMIZE CELL AND TISSUE ADHESION
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

USING THE MOUSE PERITONEAL IMPLANT MODEL, MATERIALS WILL BE EVALUATED FOR THEIR BIOCOMPATIBILITY. THE OBJECTIVE OF THISSTUDY WILL BE TO DEVELOP MATERIALS WITH MINIMAL TENDENCY FORCELLULAR AND TISSUE ADHESION. POLYURETHANES AND SILICONES, MATERIALS WIDELY USED IN BIOMEDICAL DEVICE FABRICATION, WILLBE SYNTHESIZED OR MODIFIED TO YIELD A HIGH CONCENTRATION OF POLYETHER FUNCTIONALITY AT THE POLYMER SURFACE. PREVIOUS STUDIES HAVE SHOWN THAT THE POLYETHER SURFACE PROVIDES THESEDESIRABLE CHARACTERISTICS. THE MATERIALS WILL BE EVALUATED UP TO 4 MONTHS OF IMPLANTATION TIME. PHASE II DEVELOPMENTS WILL INCLUDE ADDRESSING THE LONG-TERM STABILITY OF THE SILICONE MATERIALS, IF NECESSARY,TO PROVIDE COVALENT ATTACHMENT OF THE POLYETHER FUNCTIONALITY AT THE SURFACE UPON CURING. LONG-TERM ANIMAL STUDIES WILL BE DIRECTED TOWARD EVALUATING THE EFFECTIVENESSOF THE MATERIALS OVER TIME. THESE ANIMAL STUDIES WILL USE PROTOCOLS DIRECTED TOWARD SPECIFIC IMPLANTS AND WILL BE DONE IN COOPERATION WITH COMPANIES ALREADY PRODUCING SOFT-TISSUE IMPLANT DEVICES.

Principal Investigator:

Donald e gregonis phd
8015838444

Business Contact:

Small Business Information at Submission:

Biomaterials International Inc
420 Chipeta Way Suite 160 Salt Lake City, UT 84108

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No