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POLYMERIC MATERIALS TO MINIMIZE CELL AND TISSUE ADHESION
- Small Business Information
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Woman-Owned: NoMinority-Owned: NoHUBZone-Owned: No
- Phase 1
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Fiscal Year: 1987Title: POLYMERIC MATERIALS TO MINIMIZE CELL AND TISSUE ADHESIONAgency: HHSContract: N/AAward Amount: $50,000.00
Abstract:
USING THE MOUSE PERITONEAL IMPLANT MODEL, MATERIALS WILL BE EVALUATED FOR THEIR BIOCOMPATIBILITY. THE OBJECTIVE OF THISSTUDY WILL BE TO DEVELOP MATERIALS WITH MINIMAL TENDENCY FORCELLULAR AND TISSUE ADHESION. POLYURETHANES AND SILICONES, MATERIALS WIDELY USED IN BIOMEDICAL DEVICE FABRICATION, WILLBE SYNTHESIZED OR MODIFIED TO YIELD A HIGH CONCENTRATION OF POLYETHER FUNCTIONALITY AT THE POLYMER SURFACE. PREVIOUS STUDIES HAVE SHOWN THAT THE POLYETHER SURFACE PROVIDES THESEDESIRABLE CHARACTERISTICS. THE MATERIALS WILL BE EVALUATED UP TO 4 MONTHS OF IMPLANTATION TIME. PHASE II DEVELOPMENTS WILL INCLUDE ADDRESSING THE LONG-TERM STABILITY OF THE SILICONE MATERIALS, IF NECESSARY,TO PROVIDE COVALENT ATTACHMENT OF THE POLYETHER FUNCTIONALITY AT THE SURFACE UPON CURING. LONG-TERM ANIMAL STUDIES WILL BE DIRECTED TOWARD EVALUATING THE EFFECTIVENESSOF THE MATERIALS OVER TIME. THESE ANIMAL STUDIES WILL USE PROTOCOLS DIRECTED TOWARD SPECIFIC IMPLANTS AND WILL BE DONE IN COOPERATION WITH COMPANIES ALREADY PRODUCING SOFT-TISSUE IMPLANT DEVICES.Small Business Information at Submission:Principal Investigator:
Donald e gregonis phd
8015838444Business Contact:
Biomaterials International Inc
420 Chipeta Way Suite 160 Salt Lake City, UT 84108EIN/Tax ID:DUNS: N/ANumber of Employees: N/AWoman-Owned: NoMinority-Owned: NoHUBZone-Owned: No
Award Information
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Agency: Department of Health and Human Services |
Branch: N/A |
Award ID: 7270 |
Program Year/Program: 1987 / SBIR |
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Agency Tracking Number: 7270 |
Solicitation Year: N/A |
Solicitation Topic Code: N/A |
Solicitation Number: N/A |