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Tissue Sealant for Intracavitary Non-compressible Hemorrhage

Award Information

Agency:
Department of Defense
Branch:
Defense Advanced Research Projects Agency
Award ID:
86255
Program Year/Program:
2008 / SBIR
Agency Tracking Number:
07SB2-0064
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
BIOMEDICA MANAGEMENT CORP.
760 Parkside Ave., #304 BROOKLYN, NY -
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2008
Title: Tissue Sealant for Intracavitary Non-compressible Hemorrhage
Agency / Branch: DOD / DARPA
Contract: W31P4Q-08-C-0218
Award Amount: $98,957.00
 

Abstract:

ClotFoam is a novel crosslinked polymer designed to stop hemorrhage without compression in severe wounds outside the operating room. ClotFoam's ability to promote hemostasis in cases severe bleeding is based on the physical and coagulation properties of a fibrin sealant embedded in a gelatin support and enhanced by procoagulants, ions and molecules that increase the affinity to collagen. It is presented in 2 solutions that when mixed form a strong coating over lacerated tissue. CloFoam is delivered through a Veress needle, and distributed throughout the cavity in the form of a foam produced by a non-toxic foam inducer. Studies in rats and rabbits have shown that ClotFoam adheres to the abdominal cavity, even under profuse bleeding, initiating a rapid clot formation. Phase I proposed studies will provide the "proof of concept" for the use ClotFoam in cases of non-compressible hemorrhage by establishing its ability to adhere to lacerated tissue in a pool of blood using a rat aortic model. Phase II studies will establish the efficacy and safety in military relevant models (pigs) with induced intraperitoneal non-compressible hemorrhage secondary to grade IV/V traumatic liver damage. The study will evaluate restoration of vital functions and survival and achievement of hemostasis,

Principal Investigator:

Weiliam Chen
PI
6314442788
weiliam.chen@sunysb.edu

Business Contact:

George Falus
President
2127194799
gfalus@biomedic.net
Small Business Information at Submission:

BIOMEDICA MANAGEMENT CORP.
760 Parkside Avenue Suite 210 Brooklyn, NY 11226

EIN/Tax ID: 134073473
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No