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New Rat Model of Autoimmune Diabetes And Arthritis

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
54467
Program Year/Program:
2001 / SBIR
Agency Tracking Number:
1R43DK060374-01
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
BIOMEDICAL RESEARCH MODELS, INC.
67 MILLBROOK, ST, STE 422 WORCESTER, MA -
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2001
Title: New Rat Model of Autoimmune Diabetes And Arthritis
Agency: HHS
Contract: N/A
Award Amount: $171,353.00
 

Abstract:

DESCRIPTION (provided by applicant): The objectives of this proposal are to develop and characterize a new congenic rat model with spontaneous autoimmune disease. In Phase 1 we will establish a foundation colony of LEW.1WR1 rats and begin genetic crosses to introgress traits from BBDR/Wor and LEW.1WR strains. This should increase the incidence of spontaneous diabetes and may induce spontaneous arthritis and thyroiditis. The incidence and age of onset of type 1 diabetes, and the occurrence of spontaneous arthritis will be monitored. In Phase 2, select Quantitative Trait Loci (QTL) markers will be used to construct speed a congenic strain with a high incidence of multiple spontaneous autoimmune disorders. Some 5 percent of the U.S. population is affected by one or more autoimmune diseases. Experimental animal models facilitate the study of the pathogenesis of autoimmune diseases and permit the evaluation of treatment protocols that are not immediately feasible or ethical in humans. Animal models also provide populations of genetically uniform subjects that can be maintained under environmentally controlled conditions. It is our expectation that this new model of autoimmunity will expedite the development of safe and effective pharmaceutical agents for the treatment of Rheumatoid Arthritis, Type 1 Diabetes, and Hashimoto's Thyroiditis. PROPOSED COMMERCIAL APPLICATION: This research effort will result in a new characterized model of autoimmune diseases. The animal model will generate income by direct sales and contract research within the 15,000 sq. ft. BRM facility.

Principal Investigator:

Dennis L. Guberski

Business Contact:


5088520606
DGUBERSKI@BIOMERE.COM
Small Business Information at Submission:

BIOMEDICAL RESEARCH MODELS, INC.
10 NEW BOND ST WORCESTER, MA 01606

EIN/Tax ID: 043338250
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No