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NOVEL APPROACH TO THE PRODUCTION OF RECOMBINANT HUMAN CALCITONIN

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
7987
Program Year/Program:
1988 / SBIR
Agency Tracking Number:
7987
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Biometallics Inc
Box 2251 Princeton, NJ 08543
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1988
Title: NOVEL APPROACH TO THE PRODUCTION OF RECOMBINANT HUMAN CALCITONIN
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

CALCITONIN IS A HORMONE THAT STIMULATES THE INCORPORATION OF CALCIUM INTO BONE AND THUS ARRESTS BONE DETERIORATION PROCESSES SUCH AS POST-MENOPAUSAL OSTEOPOROSIS AND PAGET'S DISEASE. THE SYNTHETIC HORMONE CALCITONIN HAS BEEN SHOWN TO BE EFFECTIVE THERAPEUTICALLY IN ARRESTING PROGRESSIVE BONE LOSS IN THESE DISORDERS. AN ESTIMATED 24 MILLION AMERICAN WOMEN HAVE VARYING DEGREES OF OSTEOPOROSIS. PRESENTLY CALCITONIN WHICH IS PRODUCED BY SOLID PHASE PEPTIDE METHODS IS PROHIBITABLY EXPENSIVE (-$400/MG) FOR WIDESPREAD THERAPEUTIC USE. MOREOVER, THE APPLICATION OF DNA TECHNOLOGY TO THE PRODUCTION OF RELATIVELY SMALL HORMONES, SUCH AS CALCITONIN,A PEPTIDE WITH 32 AMINO ACIDS, PRESENTS SPECIAL PROBLEMS. IN THIS PROPOSAL WE PRESENT A NOVEL METHOD FOR THE HIGH YIELD PRODUCTION OF CALCITONIN USING RECOMBINANT DNA TECHNOLOGY.

Principal Investigator:


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Business Contact:

Small Business Information at Submission:

Biometallics Inc
Box 2251 Princeton, NJ 08543

EIN/Tax ID:
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No