USA flag logo/image

An Official Website of the United States Government

STABILIZATION OF ENZYMES FOR BIOREACTORS

Award Information

Agency:
National Science Foundation
Branch:
N/A
Award ID:
10763
Program Year/Program:
1989 / SBIR
Agency Tracking Number:
10763
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
SURMODICS, INC.
SURMODICS, INC. 9924 W 74TH ST EDEN PRAIRIE, MN 55344
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1989
Title: STABILIZATION OF ENZYMES FOR BIOREACTORS
Agency: NSF
Contract: N/A
Award Amount: $49,030.00
 

Abstract:

A PROJECT IS PROPOSED TO DEVELOP NEW STABILIZATION TECHNIQUES FOR IMMOBILIZED ENZYMES USED IN BIOREACTORS. THIS TECHNIQUE, WHICH HAS BEEN DEMONSTRATED TO SIGNIFICANTLYSTABILIZE AN ENZYME TO STORAGE AT ELEVATED TEMPERATURES, WILL BE FURTHER DEVELOPED AND APPLIED TO STABILIZATION OF FUNCTIONING IMMOBILIZED ENZYMES AS USED IN BIOREACTORS. THE RATIONALE IS TO PROVIDE AN ENVIRONMENT FOR OPTIMAL STABILITY SURROUNDING THE ENZME, THEN TO BIND IT TOGETHER BY COPOLYMERIZATION TO OBTAIN A VERY LARGE MOLECULAR WEIGHT,BUT SOLUBLE ENZYME DERIVATIVE. THE CROSSLINKED ENZYME WILL THEN BE IMMOBILIZED AND TESTED FOR STABILITY. THE ENZYME TOBE STABILIZED IN THIS MANNER DURING THE PHASE I PROJECT IS BETA-GALACTOSIDASE (LACTASE), WHICH IS USED IN BIOREACTORS TO HYDROLYZE LACTOSE IN MILK OR WHEY TO EITHER MAKE DAIRY PRODUCTS USABLE BY PEOPLE WITH LACTOSE INTOLERANCE OR TO MAKE A WASTE PRODUCT OF THE CHEESE INDUSTRY INTO A USEFUL PRODUCT. THE GOAL OF THE PHASE I PROJECT IS TO DOUBLE THE OVERALL USE LIFE (TOTAL HYDROLYSIS CAPACITY) OF IMMOBILIZED LACTASE BY THIS STABILIZATION TECHNIQUE.

Principal Investigator:

Melvin J Swanson
Principal Investigator
6128292700

Business Contact:

Small Business Information at Submission:

Bio-metric Systems Inc
9924 W 74th St Eden Prairie, MN 55344

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No