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RECEPTOR IMMOBILIZATION FOR AFFINITY SEPARATIONS

Award Information

Agency:
National Science Foundation
Branch:
N/A
Award ID:
14278
Program Year/Program:
1994 / SBIR
Agency Tracking Number:
14278
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
SURMODICS, INC.
SURMODICS, INC. 9924 W 74TH ST EDEN PRAIRIE, MN 55344
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 1994
Title: RECEPTOR IMMOBILIZATION FOR AFFINITY SEPARATIONS
Agency: NSF
Contract: N/A
Award Amount: $245,718.00
 

Abstract:

A PROJECT IS PROPOSED TO DEVELOP REAGENTS AND METHODS FOR IMMOBILIZING RECEPTORS ONTO POLYSULFONE MICROPOROUS MEMBRANES USED FOR AFFINITY PURIFICATION, BY PHOTOIMMOBILIZING HYDROPHILIC POLYMERIC COUPLING REAGENTS TOWHICH THE RECEPTOR WILL THEN BE COUPLED. THE TECHNIQUE IS EXPECTED TO INCREASE THE AMOUNT OF ACTIVE RECEPTOR IMMOBILIZED, TO REDUCE NONSPECIFIC BINDING AND TO INCREASE STABILITY OF THE IMMOBILIZED RECEPTOR OR ANTIBODY MOLECULES. THE TECHNOLOGY WILL BE DEVELOPED USING A MODEL ANTIBODY AFTER WHICH IT WILL ALSO BE EVALUATED FOR EFFICIENCY OF IMMOBILIZING STAPHYLOCOCCUS AUREUS PROTEIN A. USE OF THESE METHODS FOR PREPARING AFFINITY MEMBRANES IS EXPECTED TO INCREASE THE EFFICIENCY OF THE PURIFICATION PROCESS AND TO REDUCE THE COSTS OF A VARIETY OF BIOSEPARATIONS, INCLUDING PURIFICATION OF RECOMBINANT PROTEINS, ANTIBODIES AND PLASMA PROTEINS FROM CELL CULTURE SUPERNATANTS, PLASMA AND ASCITES FLUID.

Principal Investigator:

Melvin J. Swanson, Ph.d.
Principal Biochemist
0

Business Contact:

Small Business Information at Submission:

Bio-metric Systems Inc.
9924 West Seventy-fourth St Eden Prairie, MN 55344

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No