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SURFACE MODIFICATION TO IMPROVE BREAST PROSTHESES

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
18997
Program Year/Program:
1992 / SBIR
Agency Tracking Number:
18997
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
SURMODICS, INC.
SURMODICS, INC. 9924 W 74TH ST EDEN PRAIRIE, MN 55344
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1992
Title: SURFACE MODIFICATION TO IMPROVE BREAST PROSTHESES
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

THE MOST COMMON PROBLEM WITH CURRENT BREAST PROSTHESES IS THE DEVELOPMENT OF A CONTRACTILE FIBROUS CAPSULE. CAPSULAR CONTRACTURE PRODUCES BREAST HARDINING, PAIN, AND DISTORTION OF THE BREAST SHAPE. THIS PHASE I PROJECT WILL COMBINE TWO TYPES OF PROSTHESIS SURFACE MODIFICATIONS TO REDUCE CAPSULE FORMATION AND CONTRACTURE. FIRST, THE PROSTHESIS TO BE USED WILL HAVE A TEXTURE (POROUS) SILICONE RUBBER SURFACE. POROUS POLYMERS ARE REPORTED TO IMPROVE TISSUE INTEGRATION, DECREASE THE SIZE OF FIBROUS CAPSULES FORMED, AND INHIBIT THE ORDERED FORMATION OF COLLAGEN/MYOFIBRIL LAYERS THAT ARE TYPICAL OF CONTRACTED CAPSULES. SECOND, THE TEXTURED SURFACE WILL BE COATED WITH EXTRACELLULAR MATRIX (ECM) PROTEINS AND/OR PEPTIDES TO FURTHER IMPROVE TISSUE INTEGRATION BY PROMOTING THE ATTACHMENT AND INGROWTH OF BREAST TISSUE. RADIOLABELLED ECM PROTEINS AND PEPTIDES WILL BE USED TO OPTIMIZE IMMOBILIZATION EFFICIENCY ON THE PROSTHESES, AND THEIR BIOACTIVITY WILL BE EVALUATED IN VITRO BY QUANTITATING THE ATTACHMENT AND GROWTH OF FIBROBLASTS AND EPITHELIAL CELLS. COATED PROSTHESES WILL BE IMPLANTED SUBCUTANEOUSLY INTO PIGS AND HISTOLOGICALLY EVALUATED FOR TISSUE INTEGRATION AND FIBROUS ENCAPSULATION. MAMMARY PROSTEHESES ARE THE MOST COMMONLY USED SYNTHETIC IMPLANTS IN THE UNITED STATES, AND ABOUT 30% OF THESE PROSTHESES ENCOUNTER SIGNIFICANT PROBLEMS WITH CAPSULAR CONTRACTURE. THEREFORE, PROSTHESES MODIFICATIONS THATREDUCE THE INCIDENCE OF THIS PROBLEM WOULD BE EXTREMELY BENEFICIAL.

Principal Investigator:

David L Clapper
6128292700

Business Contact:

Small Business Information at Submission:

Bio-metric Systems Inc
9924 West 74th Street Eden Prairie, MN 55344

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No