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Dental Implant Coatings to Improve Gingival Attachment

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
29353
Program Year/Program:
1995 / SBIR
Agency Tracking Number:
29353
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
SURMODICS, INC.
SURMODICS, INC. 9924 W 74TH ST EDEN PRAIRIE, MN 55344
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1995
Title: Dental Implant Coatings to Improve Gingival Attachment
Agency: HHS
Contract: 1 R43 DE11225-01A1,
Award Amount: $99,998.00
 

Abstract:

We will improve the bonding of gingival tissue to osseointegrated dental implants by coating the peportion of implants with extracellular matrix (ECM) proteins. ECM proteins, which will be covalentlytransgingival implant surfaces using patented BSI photochemistry, are expected to improve the attachgingival fibroblasts and epithelial cells. Improved bonding by gingival connective tissue is expecteovergrowth of a stable epithelium that does not marsupialize. The resulting biological seal betweentissue should reduce bacterial infections and extend the useful life of dental prostheses. During Ph(fibronectin, type I collagen, and type IV collagen) will be photoimmobilized onto titanium coupons.proteins will be used to quantify the loading levels on titanium coupons. Then, each coated surfacefor attachment and growth of human fibroblasts and epithelial cells. Finally, coatings that demonstrperformance will be 1) applied to titanium one-stage implants, 2) implanted in a dog model, and 3) ehistologically for tissue integration.

Principal Investigator:

David Clapper
61229

Business Contact:

Small Business Information at Submission:

Bsi Corp.
9924 W 74th Street Eden Prairie, MN 55344

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No