Latent-Reactive Reagents for Biomaterial Surface Coating
DESCRIPTION (provided by applicant): Materials have been developed with bulk
physical properties needed for medical devices functional in the human body.
Major emphasis is now being placed on surface chemistry for implantable medical
devices to provide biocompatibility with the living tissue, as well as
lubricity for safety and ease of implantation. Radical-based surface
modification (e.g., RF plasma and photochemical diradical generation) has been
successfully developed to the point of rapid growth in commercial availability
(e.g., PhotoLink(R) coatings based on triplet carbonyl photochemistzy). These
surface modification energy sources are not effective for the inner surfaces of
"opaque" medical devices such as hollow fiber bundle membranes for hemodialysis
and blood oxygenation. This project is designed to develop latent-reactive
radical generators activatable with external source energy penetrating these
"opaque" medical devices. Phase I aims include thermal activation of new
reagents for bonding hydrophilic blood compatible polymers to biomalerials
(e.g., polypropylene, polyurethane, silicone rubber). New heterobifunctional
reagents will be developed for (1) activating the biomaterial surface, followed
by coupling to soluble polymer derivatives, or (2) incorporating into the
soluble polymer derivative followed by thermochemical coupling to the surface.
This innovative approach to scheduled activation of radical generators is
expected to facilitate the coupling to the surfaces of "inert" biomatezial
devices which cannot be illuminated with long-wavelength ultraviolet or visible
photons from external light sources.
PROPOSED COMMERCIAL APPLICATION:
Hollow fiber bundle hemodialysis and blood oxygenator membranes, luminal surface of
opaque catheters, artificial heart, heart valves, and other complex shaped implantable
devices constitute an incremental market size of ca. 260 million dollars, not subject to
surface modification with current commercial coating technology.
Small Business Information at Submission:
Principal Investigator:Patrick E. Guire
9924 W 74TH ST EDEN PRAIRIE, MN 55344
Number of Employees: