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REGENERATION WITH PDGF TREATED OSTEOCONDUCTIVE MATERIALS
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DESCRIPTION: Platelet derived growth factor-BB (PDGF-BB) has been shown to
stimulate periodontal wound healing in both animals and humans. Certain Bone substitutes
have also been shown to enhance periodontal regeneration in both animal models and
in humans. The investigators have demonstrated that PDGF can be adsorbed to
that PDGF is slowly released in vitro. Addition of PDGF has been shown to enhance the
in vitro osteoblastic cell attachment and proliferation compared to untreated.
The hypothesis of the application is that PDGF treatment will enhance the periodontal
regenerative properties of these osteoconductive materials. The Specific Aims
of the application are to determine if combined with PDGF
promotes greater periodontal regeneration in the beagle dog than unmodified,
to determine the concentration of PDGF that when added to the
stimulates the greatest amount of regeneration, and to
determine if any abnormal healing responses in the periodontal defects such and
ankylosis and root resorption occur with the use of the PDGF treated .
PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE
* Information listed above is at the time of submission. *
