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THE GOAL OF THIS RESEARCH IS TO DEVELOP A HIGHLY SENSITIVE AND SPECIFIC…

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
4965
Program Year/Program:
1986 / SBIR
Agency Tracking Number:
4965
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Biomol Research Laboratoryt
5166 Campus Drive Plymouth Meeting, PA 19462
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1986
Title: THE GOAL OF THIS RESEARCH IS TO DEVELOP A HIGHLY SENSITIVE AND SPECIFIC RADIOIMMUNOASSAY FOR LEUKOTRIENE E4 AND LEUKOTRIENE E4-N-ACETATE, TWO IMPORTANT METABOLITES OF LEUKOTRIENE C4 AND D4.
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

THE GOAL OF THIS RESEARCH IS TO DEVELOP A HIGHLY SENSITIVE AND SPECIFIC RADIOIMMUNOASSAY FOR LEUKOTRIENE E4 AND LEUKOTRIENE E4-N-ACETATE, TWO IMPORTANT METABOLITES OF LEUKOTRIENE C4 AND D4. THESE LEUKOTRIENES ARE POTENT BRONCO- AND CORONARY ARTERY VASOCONSTRICTORS, INCREASE VASCULAR PERMEABILITY, STIMULATE MUCUS SECRETION, AND CAUSE LONG-LASTING HYPOTENSION, THUS PLAYING A PATHOPHYSIOLOGICAL ROLE IN IMMEDIATE HYPERSENSITIVITY REACTIONS, INFLAMMATION, AND TISSUE TRAUMA. SPECIFIC AIMS OF THIS PROJECT INCLUDE: (1) PREPARATION OF A NUMBER OF LEUKOTRIENE E4 AND LEUKOTRI- ENE E4-N-AC-PROTEIN CONJUGATES HAVING VARIOUS MODES OF LEUKOTRIENE TO PROTEIN LINKAGE; (2) PRODUCTION OF ANTIBODIESTO EACH CONJUGATE BY IMMUNIZATION OF RABBITS; (3) COMPARISONOF THE ANTIBODIES AND SELECTION OF THOSE WITH HIGHEST SPECIFICITY AND SENSITIVITY; AND (4) PRODUCTION OF LEUKOTRIENE E4 AND E4-N-AC RADIOIMMUNOASSAY KITS FOR COMMERCIALIZATION. A LARGE NUMBER OF PHARMACEUTICAL COMPANIES ARE DEVELOPING SPECIFIC THERAPEUTIC AGENTS BASED ON LEUKOTRIENE INHIBITION AND/OR ANTAGONISM, AND THESE KITS ARE EXPECTED TO FIND WIDE APPLICATION.

Principal Investigator:

Robert e zipkin
PRINCIPAL INVESTIGATOR
2158741433

Business Contact:

Small Business Information at Submission:

Biomol Research Laboratories
Front & Lloyd Streets Chester, PA 19013

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No