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RADIO IMMUNOASSAY KITS FOR PLATELET ACTIVATING FACTOR

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
8052
Program Year/Program:
1988 / SBIR
Agency Tracking Number:
8052
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Biomol Research Laboratoryt
5166 Campus Drive Plymouth Meeting, PA 19462
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1988
Title: RADIO IMMUNOASSAY KITS FOR PLATELET ACTIVATING FACTOR
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

THE GOAL OF THE PROPOSED RESEARCH IS TO DEVELOP A HIGHLY SENSITIVE AND SPECIFIC RADIOIMMUNOASSAY FOR PLATELET ACTIVATING FACTOR (PAF). PAF IS A LIPID MEDIATOR PRODUCED BY A VARIETY OF INFLAMMATORY CELLS SUCH AS NEUTROPHILS, PLATELETS, MACROPHAGES, EOSINOPHILS, AND VASCULAR ENDOTHELIAL CELLS. PAF INDUCES A NUMBER OF IN VIVO EFFECTS INCLUDING ACUTE BRONCHOCONSTRICTION AND BRONCHOPULMONARY HYPERREAC-TIVITY ACCOMPANIED BY PLATELET, EOSINOPHIL, AND MACROPHAGE ACTIVATION AND RECRUITMENT. THUS THE ROLE OF PAFIN THE PATHOPHYSIOLOGY OF IMMEDIATE HYPERSENSITIVITY REACTIONS, ESPECIALLY ASTHMA, AND INFLAMMATION IS APPARENT. SPECIFIC AIMS INCLUDE: 1) PREPARATION OF A METABOLICALLY STABLE PAF DERIVATIVE SUITABLY FUNCTIONALIZED FOR PROTEIN CONJUGATION, 2) PREPARATION OF A PAF-PROTEIN CONJUGATE. 3) PRODUCTION OF ANTIBODIES TO THE CONJUGATE BY IMMUNIZATION OF RABBITS, 4) PRODUCTION OF PAF RADIOIMMUNOASSAY KITS FOR COMMERCIAL-IZATION. A LARGE NUMBER OF PHARMACEUTICAL COMPANIES ARE DEVELOPING NOVEL AND MORE SPECIFIC THERAPEUTIC AGENTS BASED ON PAF INHIBITION OR ANTAGONISM AND THESE KITS ARE EXPECTED TO FIND WIDE APPLICATION.

Principal Investigator:


0

Business Contact:

Small Business Information at Submission:

Biomol Research Laboratories
5166 Campus Dr Plymouth Meeting, PA 19462

EIN/Tax ID:
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No