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CONTROLLED-PERMEABILITY CONTAINER FOR FREEZING SPERM

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
7964
Program Year/Program:
1988 / SBIR
Agency Tracking Number:
7964
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
BIOPORE, INC.
BIOPORE, INC. 2011 PINE HALL DR STATE COLLEGE, PA 16803
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1988
Title: CONTROLLED-PERMEABILITY CONTAINER FOR FREEZING SPERM
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

DEPSITE ADVANTAGES OF DISEASE CONTROL, FROZEN HUMAN SPERM HAS BEEN RARELY USED UNIVERSALLY FOR DONOR ARTIFICIAL INSEMINATION BECAUSE OF PERCEIVED LOW FERTILITY. GLYCEROL (WHICH MAY BE CONTRACEPTIVE IN HUMANS AS WITH OTHER SPECIES) AND EGG YOLK PROTEIN (WHICH MAY BE ANTIGENIC) CAN BE REMOVED BY SERIAL DILUTION OR CENTRIFUGATION; SUCH PROCESSES DAMAGE SPERM. WE ARE DEVELOPING PRACTICAL APPROACHES FOR USE OF CRYOPRESERVED SPERM. WE WILL EVALUATEA SEMINAL CONTAINER WHICH: (A) IS INSOLUBLE IN AQUEOUS MEDIADURING LOADING AND FREEZING; (B) DEVELOPS, AFTER THAWING ANDIMMERSION IN APPROPRIATE DILUENT SOLUTIONS, PORES WHOSE SIZEAND NUMBER ALLOW EGRESS OF EXTENDER AND CRYOPROTECTANT AT A CONTROLLED RATE (MINIMIZING CELL DAMAGE) WHILE SPERM REMAIN IN THE CONTAINER; AND (C) IS DIRECTLY ATTACHABLE TO ADEVICE FOR FACILE INSEMINATION. CHICKEN SEMEN WILL BE USED BECAUSE OF (A) SENSITIVITY OF THEIR SPERM TO CRYOPROTECTANT AND FREEZE-THAW DAMAGE AND (B) STATISTICALLY VALID FERTILITYDATA ARE EASILY OBTAINED. FIVE EXPERIMENTS WILL EVALUATE: (A) RATE OF EGRESS OF CRYOPROTECTANT FROM THE CONTAINER; (B) LACK OF TOXICITY OF CONTAINER MATERIAL TO SPERM; (C) EXTENT OF DAMAGE TO SPERM WHEN CONTAINERS ARE TESTED FOR REMOVAL OF CRYOPROTECTANT FROM UNFROZEN SAMPLES; (D) AS IN (C) BUT FROZEN-THAWED SPERM; AND (E) FERTILITY OF SPERM CRYOPRESERVED IN THESE PROTOTYPE CONTAINERS.

Principal Investigator:


0

Business Contact:

Small Business Information at Submission:

Reproduction Resources
Box 482 101 N Pennsylvania Ave Centre Hall, PA 16828

EIN/Tax ID:
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No