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Large Throughput Multiplex Analysis of Gene Expression

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
29250
Program Year/Program:
1995 / SBIR
Agency Tracking Number:
29250
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
Genaissance Pharmaceuticals
Five Science Park New Haven, CT 06511
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Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1995
Title: Large Throughput Multiplex Analysis of Gene Expression
Agency: HHS
Contract: 1 R43 CA68853-01,
Award Amount: $100,000.00
 

Abstract:

We will develop resources for large-throughput analysis of gene expression. The complement of genesexpressed in a given cell varies during development, in disease states and in response to hormonal sgene expression are the basis of cancer. This project will show the feasibility of "Multiplex Profillarge-throughput strategy for characterizing changes in gene expression and for retrieving the variaperform MP on gene transcripts synthesized by two methods targeted to open reading frames and 5' regdevelop conditions for multiplex electrophoresis of PCR products and for hybridization and retrievaltranscripts with "signature" oligonucleotides derived from conserved protein motifs. MP will be appland normal respiratory epithelium cell lines using signature oligos for G proteins. The differentialcould become molecular markers for these tumors.

Principal Investigator:

Gualberto Ruano
20373

Business Contact:

Small Business Information at Submission:

Bios Laboratorytories, Inc.
5 Science Park New Haven, CT 06511

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No